67029-85-0Relevant academic research and scientific papers
Palladium-catalyzed asymmetric conjugate addition of arylboronic acids to heterocyclic acceptors
Holder, Jeffrey C.,Marziale, Alexander N.,Gatti, Michele,Mao, Bin,Stoltz, Brian M.
supporting information, p. 74 - 77 (2013/02/25)
Flava Flavanone: Asymmetric conjugate additions to chromones and 4-quinolones are reported utilizing a single catalyst system formed in situ from Pd(OCOCF3)2 and (S)-tBuPyOX. Notably, these reactions are performed in wet solvent under ambient atmosphere, and employ readily available arylboronic acids as the nucleophile, thus providing ready access to these asymmetric heterocycles (see scheme).
Synthesis of 7-hydroxy-6H-benzo[c]chromen-6-ones based on?a '[3+3] cyclization/domino retro-Michael-aldol-lactonization' strategy
Ullah, Ehsan,Appel, Bettina,Fischer, Christine,Langer, Peter
, p. 9694 - 9700 (2007/10/03)
The TiCl4-mediated [3+3] cyclization of 2,4-bis(trimethylsilyloxy)penta-1,3-diene with 3-silyloxyalk-2-en-1-ones afforded 2-acetylphenols, which were transformed into functionalized chromones. The Me3SiOTf-mediated condensation of the latter with 1,3-bis(silyl enol ethers) and subsequent domino 'retro-Michael-aldol-lactonization' reaction afforded 7-hydroxy-6H-benzo[c]chromen-6-ones.
