6705-23-3

Usage

Uses

Used in Pharmaceutical Industry:
2-(piperidin-1-yl)pyrazine serves as a crucial intermediate in the synthesis of various drugs, contributing to the development of new medications and APIs. Its structural components, particularly the piperidine ring, are integral to its role in drug synthesis, potentially leading to the creation of compounds with enhanced therapeutic effects.
Used in Research and Development:
In the realm of medicinal chemistry, 2-(piperidin-1-yl)pyrazine is employed as a research compound, facilitating the exploration of its antiviral and antitumor properties. 2-(piperidin-1-yl)pyrazine's potential in these areas is currently under investigation, with the aim of identifying new therapeutic strategies for viral infections and cancer treatment.
Used in Antiviral Applications:
2-(piperidin-1-yl)pyrazine is being studied for its potential as an antiviral agent, with the hope of developing new treatments for viral diseases. 2-(piperidin-1-yl)pyrazine's structure and biological activity may offer a novel approach to combating viral infections, providing an alternative to existing antiviral medications.
Used in Antitumor Applications:
2-(piperidin-1-yl)pyrazine is also being investigated for its antitumor properties, with the goal of identifying its potential as a cancer treatment. The piperidine group in 2-(piperidin-1-yl)pyrazine may play a role in its interaction with tumor cells, offering a new avenue for cancer research and therapeutic development.

Upstream product

• 110-89-4 piperidine 
• 14508-49-7 2-chloropyrazin 

Relevant academic research and scientific papers

Synthesis and fluorescence properties 2-N-piperidinopyrazines

2-N-Piperidinopyrazine, 2-N-(3-methyl)piperidinopyrazine and 2-N-(4-methyl)piperidinopyrazine were synthesized by reacting 2-chloropyrazine with piperidine, 3-methylpiperidine, 4-methylpiperidine respectively. The structures of these compounds were confir

Pd/PTABS: Catalyst for Room Temperature Amination of Heteroarenes

A mild and highly efficient catalytic amination procedure for chloroheteroarenes at ambient temperature using the Pd/PTABS catalytic system is reported. The protocol is selective for the amination of chloroheteroarenes using secondary amines such as piperidine, pyrrolidine, and several others. The exceptional mildness of the developed protocol is beneficial for the synthesis of a crucial Buparlisib intermediate as well as the formal synthesis of Alogliptin in competitive yields.

Towards aryl C-N bond formation in dynamic thin films

C-N bond forming reactions are important in organic chemistry. A thin film microfluidic vortex fluidic device (VFD) operating under confined mode affords N-aryl compounds from 2-chloropyrazine and the corresponding amine, without the need for a transition

2,3-Diaminopyrazines as rho kinase inhibitors

Inhibition of rho kinase (ROCK) has been recognized as an important target for a number of diseases, including glaucoma. Herein we report SAR development around two hits from a kinase library that led to the discovery of the ROCK inhibitor compound 38. In vitro and in vivo analysis of this compound, including its effects in a monkey model of glaucoma will be discussed.

Aminopyrazine analogs for treating glaucoma and other rho kinase-mediated diseases and conditions

Methods for using aminopyrazine analogs to treat rho kinase-mediated diseases or rho kinase-mediated conditions, including controlling intraocular pressure and treating glaucoma, are disclosed. Ophthalmic pharmaceutical compositions useful in the treatment of eye diseases such as glaucoma, and additionally useful for controlling intraocular pressure, the compositions comprising an effective amount of aminopyrazine analogs, are also disclosed.

Efficient nucleophilic substitution reactions of pyrimidyl and pyrazyl halides with nucleophiles under focused microwave irradiation

Rapid nucleophilic displacement reactions of 2-chloropyrimidine, 2-bromopyrimidine, 5-bromopyrimidine and chloropyrazine with nucleophiles under microwave irradiation was complete within several minutes with yields up to 99%. The method using microwave irradiation is superior to the classical heating processes.