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5-Isopentyl-5-methylbarbituric acid, also known as 5-ethyl-5-(3-methylbutyl)-2,4,6(1H,3H,5H)-pyrimidinetrione, is a chemical compound with the molecular formula C10H16N2O3. It is a derivative of barbituric acid, characterized by the presence of an isopentyl group (3-methylbutyl) and a methyl group attached to the 5-position of the barbituric acid structure. 5-Isopentyl-5-methylbarbituric acid is primarily used as a sedative and hypnotic agent, with its effects attributed to its ability to depress the central nervous system. It is important to note that the use of barbiturates like 5-isopentyl-5-methylbarbituric acid has declined due to their potential for abuse, dependence, and adverse side effects, and they have been largely replaced by safer alternatives in modern medicine.

67051-30-3

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67051-30-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 67051-30-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,7,0,5 and 1 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 67051-30:
(7*6)+(6*7)+(5*0)+(4*5)+(3*1)+(2*3)+(1*0)=113
113 % 10 = 3
So 67051-30-3 is a valid CAS Registry Number.
InChI:InChI=1/C10H16N2O3/c1-6(2)4-5-10(3)7(13)11-9(15)12-8(10)14/h6H,4-5H2,1-3H3,(H2,11,12,13,14,15)

67051-30-3Relevant academic research and scientific papers

INFLUENCE DE LA LIPOPHILIE SUR L'OXYDATION BIOLOGIQUE D'UNE CHAINE METHYL-3 BUTYLE EN SERIE BARBITURIQUE

Lafont, Olivier,Talab, Akram,Menager, Sabine,Cave, Christian,Miocque, Marcel

, p. 427 - 432 (2007/10/02)

Influence of lipophilicity on biological oxidation of a 3-methylbutyl side chain in a barbiturate series.The lipophilic character of 5-methyl-5-(3-methylbutyl) barbituric acid 3 is lower (Δ logP=0.5) than that of amobarbital, itself lower (Δ logP=0.5) than that of 5-(3-methylbutyl)-5-propyl barbituric acid.The influence of these differences upon biological oxidation was studied.Models of various potential metabolites of 3 were synthesized and compound 3 was administered to rats and dogs. 6.4percent (dogs) or 5.3percent (rats) of non-modified compound 3 and 53.1percent (dogs) or 59.6percent (rats) of a γ-hydroxylated metabolite were recorved in urine.These results compared with those obtained for related compounds show that the influence of lipophilicity upon biological oxidation is not as important as one could suppose.Keywords - lipophilicity / metabolism / barbiturates / chromic oxidation / biological hydroxylation / hydroxybarbiturates

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