6708-35-6

Basic information

• Product Name: [(3S)-4-Oxo-4-hydroxy-3-aminobutyl]dimethylsulfonium
• Synonyms: (S)-2-Amino-4-(dimethylsulfonio)butanoic acid;[(3S)-4-Oxo-4-hydroxy-3-aminobutyl]dimethylsulfonium;[(S)-3-Amino-3-carboxypropyl]dimethylsulfonium;Dimethyl[(S)-3-amino-3-carboxypropyl]sulfonium;L-Methylmethionine sulfonium;(2S)-2-azaniumyl-4-dimethylsulfoniobutanoate
• CAS NO: 6708-35-6
• Molecular Formula: C6H14NO2S
• Molecular Weight: 0
• Mol File: 6708-35-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: [(3S)-4-Oxo-4-hydroxy-3-aminobutyl]dimethylsulfonium(CAS DataBase Reference)
• NIST Chemistry Reference: [(3S)-4-Oxo-4-hydroxy-3-aminobutyl]dimethylsulfonium(6708-35-6)
• EPA Substance Registry System: [(3S)-4-Oxo-4-hydroxy-3-aminobutyl]dimethylsulfonium(6708-35-6)

Safety Data

• Hazardous Substances Data: 6708-35-6(Hazardous Substances Data)

Upstream product

• 63-68-3 L-methionine 
• 74-88-4 methyl iodide 

Downstream Products

• 672-15-1 L-homoserine 
• 44743-29-5 Dimethyl-propiothetin 

Relevant articles and documents

Synthesis and delivery of a stable phosphorylated ubiquitin probe to study ubiquitin conjugation in mitophagy

Protein post-translational modifications are involved in essentially all aspects of cellular signaling. Their dynamic nature and the difficulties in installing them using enzymatic approaches limits their direct study in human cells. Reported herein is the first synthesis, delivery and cellular study of a stable phosphoubiquitin probe. Our results compare Parkin's substrate preference during mitophagyviadirect visualization of a phosphorylated ubiquitin probe in the cellular environment.

Synthesis and biological evaluation of novel curcuminoid derivatives

Curcuminoids have been reported to possess multiple bioactivities, such as antioxidant, anticancer and anti-inflammatory properties. Three novel series of curcuminoid derivatives (11a-h, 15a-h and 19a-d) with enhanced bioactivity have been synthesized. Among the synthesized compounds, 11b exhibited the most significant activity with an MIC of 0.5 μ M /mL against selected medically important Gram-positive cocci (S aureus and S viridans) and Gram-negative bacilli (E. coli and E. cloacae). The derivatives exhibited remarkable results in an antioxidant test with an IC50 2.4- to 9.3-folder smaller than curcuminoids. With respect to antiproliferative activity against Hep-G2, LX-2, SMMC7221 and MDA-MB-231, the derivatives exhibited an effect stronger than curcuminoids with an IC50 ranging from 0.18 to 4.25 μ M.