67087-19-8

Basic information

• Product Name: ethyl 5-[bis(4-ethoxycarbonyl-3,5-dimethyl-1H-pyrrol-2-yl)methyl]-2,4- dimethyl-1H-pyrrole-3-carboxylate
• Synonyms: ethyl 5-[bis(4-ethoxycarbonyl-3,5-dimethyl-1H-pyrrol-2-yl)methyl]-2,4- dimethyl-1H-pyrrole-3-carboxylate
• CAS NO: 67087-19-8
• Molecular Formula: C28H37N3O6
• Molecular Weight: 511.61
• Mol File: 67087-19-8.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ethyl 5-[bis(4-ethoxycarbonyl-3,5-dimethyl-1H-pyrrol-2-yl)methyl]-2,4- dimethyl-1H-pyrrole-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 5-[bis(4-ethoxycarbonyl-3,5-dimethyl-1H-pyrrol-2-yl)methyl]-2,4- dimethyl-1H-pyrrole-3-carboxylate(67087-19-8)
• EPA Substance Registry System: ethyl 5-[bis(4-ethoxycarbonyl-3,5-dimethyl-1H-pyrrol-2-yl)methyl]-2,4- dimethyl-1H-pyrrole-3-carboxylate(67087-19-8)

Safety Data

• Hazardous Substances Data: 67087-19-8(Hazardous Substances Data)

Upstream product

• 86770-31-2 2-tert-butyl 4-ethyl 3,5-dimethyl-1H-pyrrole-2,4-dicarboxylate 
• 122-51-0 orthoformic acid triethyl ester 

Relevant articles and documents

Selective synthesis and utility of one tripyrrolic compound and its intermediates

Highly selective syntheses of tri(2,4-dimethyl-3-carbethoxypyrrolyl)- methane 8 and its dipyrrolic intermediate 6 and pyrrolic one 1 are described based on the successful correction of the wrong process for 1 in literature. Tripyrrolic compounds have attracted much attention recently and been developed in diverse fields. 1 was the key intermediate for some tyrosine kinase inhibitors, including newly-launched Sutent, and most recently we have found 6 was also synthetically useful in the synthesis of 11 that has been discovered as a novel histone deacetylases (HDAC) inhibitor with an IC 50 value of about 1 μM in our assessments and represents a promising lead for the development of more potent histone deacetylase inhibitors (HDACIs).