67101-63-7

Upstream product

• 587-03-1 3-methylbenzyl alcohol 
• 111-27-3 hexan-1-ol 
• 808148-29-0 t-butyl benzyl(3-methylbenzoyl)carbamate 

Relevant academic research and scientific papers

Preparation method for synthesizing ester compound by using N-Boc amide as raw material

The invention relates to a preparation method for synthesizing an ester compound by using N-Boc amide as a raw material. According to the method, an inorganic base is used as a catalyst; the N-Boc amide is subjected to an intermolecular nucleophilic substitution reaction with various alcohol compounds; and various ester compounds can be efficiently obtained. The method has the advantages of beingmild in reaction condition, simple and convenient to operate, high in yield and favorable in functional-group compatibility.

Cesium Carbonate Catalyzed Esterification of N-Benzyl- N-Boc-amides under Ambient Conditions

We report a general activated amide to ester transformation catalyzed by Cs2CO3. Using this approach, esterification proceeds under relatively mild conditions and without the need for a transition metal catalyst. This method exhibits broad substrate scope and represents a practical alternative to existing esterification strategies. The synthetic utility of this protocol is demonstrated via the facile synthesis of crown ether derivatives and the late-stage modification of a representative natural product and several sugars in reasonable yields.

General and selective palladium-catalyzed oxidative esterification of alcohols

Selectively esterified: Primary alcohols react with dioxygen as a benign oxidant in a palladium-catalyzed oxidative esterification (see scheme). The corresponding aldehydes and esters are formed highly selectively depending on the catalyst system. The reactions take place in the presence of commercially available ligands without the need for additional organic hydrogen acceptors. Copyright