67106-14-3

Upstream product

• 95-92-1 oxalic acid diethyl ester 
• 102-04-5 1,3-Diphenylpropanone 

Downstream Products

• 54714-22-6 3,4-carbonyldioxy-2,5-diphenyl-cyclopentadienone 
• 100075-04-5 (Z)-5-benzylidene-4-ethoxycarbonylmethoxy-3-phenylfuran-2(5H)-one 
• 100075-02-3 (Z)-4-benzoyloxy-5-benzylidene-3-phenylfuran-2(5H)-one 
• 100075-01-2 (Z)-5-benzylidene-3-phenyl-4-pivaloyloxyfuran-2(5H)-one 
• 100075-00-1 (Z)-5-benzylidene-4-isobutyryloxy-3-phenylfuran-2(5H)-one 
• 100075-03-4 (Z)-5-benzylidene-4-allyloxy-3-phenylfuran-2(5H)-one 
• 100074-81-5 (Z)-4-acetoxy-5-benzylidene-3-phenylfuran-2(5H)-one 
• 100074-92-8 4-methoxy-3-phenyl-5-(phenylmethylene)furan-2(5H)-one 
• 88288-79-3 1,4,5,7-Tetraphenyl-1,2,3,4-tetrahydro-cyclopentapyrazin-6-one 
• 88288-78-2 1,4-dimethyl-5,7-diphenyl-1,2,3,4-tetrahydro-6H-cyclopenta[b]pyrazin-6-one 

Relevant academic research and scientific papers

Ruthenium-Catalyzed Three-Component Alkylation: A Tandem Approach to the Synthesis of Nonsymmetric N,N-Dialkyl Acyl Hydrazides with Alcohols

The borrowing hydrogen strategy has been applied in the synthesis of nonsymmetric N,N-dialkylated acyl hydrazides via a tandem three-component reaction catalyzed by a phosphine free diaminocyclopentadienone ruthenium tricarbonyl complex. This strategy represents the first direct one-pot approach to nonsymmetric functionalized acyl hydrazides. Different aromatic acyl hydrazides underwent dialkylation with a variety of primary or secondary alcohols and methanol or ethanol as alkylating agents in mild reaction conditions and good yields. Deuterium labelling experiments suggested that the primary or secondary alcohol was the hydrogen source in this tandem process. DFT calculations show that the combination of the tandem mixed product cannot be perfectly explained neither structurally nor electronically, but might be dependent of the physical state of the aldehyde or ketone intermediate (gaz vs. liquid) at the reaction temperature. (Figure presented.).

Iron-Catalyzed Chemoselective Reduction of α,β-Unsaturated Ketones

An iron-catalyzed chemo- and diastereoselective reduction of α,β-unsaturated ketones into the corresponding saturated ketones in mild reaction conditions is reported herein. DFT calculations and experimental work underline that transfer hydride reduction is a more facile process than hydrogenation, unveiling the fundamental role of the base.

Well-Defined Phosphine-Free Iron-Catalyzed N-Ethylation and N-Methylation of Amines with Ethanol and Methanol

An iron(0) complex bearing a cyclopentadienone ligand catalyzed N-methylation and N-ethylation of aryl and aliphatic amines with methanol or ethanol in mild and basic conditions through a hydrogen autotransfer borrowing process is reported. A broad range of aromatic and aliphatic amines underwent mono- or dimethylation in high yields. DFT calculations suggest molecular hydrogen acts not only as a reducing agent but also as an additive to displace thermodynamic equilibria.

Synthesis of (E)- and (Z)-Pulvinones

Two new routes to pulvinones have been developed, one of which involves a novel Wittig reaction.For the first time, members of the E-series, including the parent (E)-pulvinone, are reported and the structural elucidation of the geometric isomers is descri