67117-20-8

Upstream product

• 50289-06-0 4-hydroxypiperidine-4-carboxylic acid 
• 501-53-1 benzyl chloroformate 
• 1008779-96-1 1-benzyl-4-methyl-4-hydroxypiperidine-1,4-dicarboxylate 
• 13139-17-8 N-(Benzyloxycarbonyloxy)succinimide 
• 495414-65-8 4-hydroxypiperidine-4-carboxylic acid hydrochloride 

Downstream Products

• 330934-68-4 benzyl 1-benzyloxycarbonyl-4-hydroxypiperidine-4-carboxylate 

Relevant academic research and scientific papers

Gold(I)-Catalyzed Intramolecular Hydroamination and Hydroalkoxylation of Alkynes: Access to Original Heterospirocycles

We report here a simple and robust gold-catalyzed annulation reaction, giving N- and O-spirocycles in good to excellent yields. We have prepared a library of protected amines and tertiary alcohols that give, upon cyclization with alkynes, a representative set of heterospirocycles and illustrate reaction compatibility with diverse functional groups. A change in catalytic activity is possible by modifying the solvent, and two original tricyclic spirocycles were synthesized in a tandem reaction.

Preparation method of oxazaspiro compound

The invention discloses a preparation method of an oxazaspiro compound, which comprises the following steps: by using substituted saturated azaspiro alkane (compound II) as a raw material, performinghydrolyzing under an alkaline condition to obtain a compound III; carrying out condensation reaction on the compound III and a salt of a compound IV (halogenated alkylamine)/compound IV to generate acompound V; and finally, cyclizing the compound V under an alkaline condition to obtain the lactam oxazaspiro compound I.

Phosphonic acid derivatives having carboxypeptidase b inhibitory activity

A compound represented by the following general formula (I) and a pharmacologically acceptable salt thereof: wherein R1represents hydrogen atom, an alkyl group, a substituted alkyl group and the like; R2and R3represent hydrogen atom, an alkyl group, a substituted alkyl group, an alkoxyl group and the like; X represents —CH2—, —O—, or —NH—; A represents the following group (II): [in which R7and R8represent hydrogen atom, an alkyl group, an acyl group, an alkoxycarbonyl group and the like; R9and R10represents hydrogen atom, a halogen atom, hydroxyl group, phenyl group, an alkyl group and the like] and the like; and E represents hydrogen atom and the like, which has inhibitory activity against carboxypeptidase B and is useful for therapeutic and/or preventive treatment of a thrombotic disease.