671232-87-4

Upstream product

• 199850-56-1 methyl 2-amino-4-chloro-5-iodobenzoate 
• 335293-23-7 3,4,5-trimethylphenylacetyl chloride 
• 5900-58-3 2-amino-4-chloro-benzoic acid methyl ester 
• 51719-67-6 3,4,5-trimethylphenylacetic acid 

Downstream Products

• 671232-88-5 7-chloro-4-hydroxy-6-iodo-3-(3,4,5-trimethylphenyl)-1H-quinolin-2-one 
• 671232-89-6 4-(2-(N-t-butoxycarbonylazetidin-2(S)-yl)ethoxy)-7-chloro-6-iodo-3-(3,4,5-trimethylphenyl)-1H-quinolin-2-one 

Relevant academic research and scientific papers

Synthesis of two non-peptidyl GnRH receptor antagonists via [ 14C]carbonylation

In support of a program to develop a new gonadotropin releasing hormone (GnRH) receptor antagonist, two 14C labelled candidate tracers, 14C-1 and 14C-2, were synthesized for utilization in metabolism studies. A slight modi

Quinolones as gonadotropin releasing hormone (GnRH) antagonists: Simultaneous optimization of the C(3)-aryl and C(6)-substituents

A series of 3-arylquinolones was prepared and evaluated for their ability to act as gonadotropin releasing hormone (GnRH) antagonists. A variety of substitution patterns of the 3-aryl substituent are described. The 3,4,5-trimethylphenyl substituent (23h) was found to be optimal. (C) 2000 Elsevier Science Ltd. All rights reserved.