67124-65-6

Upstream product

• 110-05-4 di-tert-butyl peroxide 
• 71098-82-3 cyclohexyl(imino)(phenyl)-λ⁶-sulfanone 
• 111-24-0 1,5-dibromo-pentane 
• 30004-67-2 N,S-dimethyl-S-phenylsulfoximine 
• 420-37-1 trimethoxonium tetrafluoroborate 

Relevant academic research and scientific papers

N - methylation of the sulfoxide of imine derivative (by machine translation)

A simple, clean and high-effective synthetic method of a novel N-methylated sulfoximine derivative is provided in the invention. The invention relates to the fields of pesticides, organic chemical engineering and fine chemical engineering. The method essentially is an organic synthesis reaction that a methyl free radical, which is generated from peroxides, and a sulfoximine compound are subjected to free radical coupling to form new C-N bonds. The method includes the step of carrying out a reaction to obtain the N-methylated sulfoximine derivative in a common organic solvent under a heating condition from the raw materials including diphenyl sulfoximine and a methylating reagent (peroxides) under the catalysis by copper. The method is 2-20 h in reaction time under a heating and stirring condition. The molar ratio of the raw materials is that the diphenyl sulfoximine to the methylating reagent is 1:0.5-3.0. The raw materials are reacted under the heating condition and then reaction products are subjected to simple after treatments to obtain the N-methylated sulfoximine derivative at a yield being 36-87%. The invention develops a series of N-methylating methods based on a free radical process to prepare a series of N-methylated sulfoximine derivatives. The method is simple in operation and after treatments, and is simple and practical in synthesis of these compounds.

Copper-catalyzed N-methylation/ethylation of sulfoximines

A protocol for the copper-catalyzed N-methylation of sulfoximines with di-tert-butyl peroxide (DTBP) was developed. This protocol has good functional group tolerance leading to N-methylated sulfoximines in moderate to good yields. Besides, N-ethylation of sulfoximines was achieved in the presence of bis(1,1-dimethylpropyl)peroxide as the ethylating agent under a standard procedure.

Synthesis of phosphanyl sulfoximines through phospha-michael reaction of alkenyl sulfoximines and their evaluation as chiral bidentate 1, 5-N, P ligands for palladium in asymmetric allylic alkylation

The intermolecular phospha-Michael reaction of cyclic and acyclic alkenyl sulfoximines proceeds readily and yields the corresponding phosphanyl sulfoximines in good yield. The asymmetric induction provided, by sulfoximine group in C-P bond formation is ap