671247-39-5Relevant academic research and scientific papers
Self-catalytic Michael reaction of enolizable carbonyl compounds. A facile route to α-methylene-δ-valerolactones
Krawczyk, Henryk,?liwiński, Marcin
, p. 9199 - 9211 (2007/10/03)
Various dicyclohexylammonium 2-phosphono-5-oxoalkanoates 3 were prepared by the Michael reaction of enolizable carbonyl compounds with the acrylate 1. The corresponding 2-phosphono-5-oxoalkanoic acids 4 were converted into α-phosphono-δ-valerolactones 6. The products were shown to be useful substrates for the synthesis of α-methylene-δ-valerolactones 7 by the Horner-Wadsworth-Emmons reaction.
