67139-62-2Relevant academic research and scientific papers
Benzylidene-Thiolactone Rearrangement: Synthesis and Rearrangement of 5-Substituted 3-Benzylidene-4-thiolen-2-ones
Heindel, Ned D.,Conley, Richard A.,Minatelli, John A.,Boschelli, Diane Harris
, p. 3051 - 3053 (2007/10/02)
Condensation of 5-substituted 4-thiolen-2-ones (1) with aromatic aldehydes (2) in anhydrous ethanolic HCl generates the 3-benzylidene derivatives 3.These can be rearranged in base (benzylidene-thiolactone rearrangement) to 2,5-disubstituted thiophene-3-carboxylic acids (4, 5, or 6).
