67140-85-6 Usage
Chemical Structure
A benzene ring with two amine groups (NH2) attached to the 1 and 3 positions, and two isopropyl groups (C3H7) attached to the 2 and 6 positions.
Antioxidant in rubber products
Used to protect rubber products like tires and conveyor belts from degradation caused by oxygen and ozone.
Manufacturing of dyes and hair dyes
Used as a chemical intermediate in the production of various dyes and hair coloring products.
Synthesis of pharmaceuticals
Utilized in the synthesis of certain pharmaceutical compounds.
Toxicity
Can be harmful if ingested, inhaled, or absorbed through the skin.
Irritation
May cause irritation to the eyes, skin, and respiratory system.
Potential for genetic mutations
May have the potential to cause genetic mutations.
Environmental impact
May be harmful to aquatic organisms.
Safety Precautions
Handle with care, use appropriate personal protective equipment (PPE) such as gloves, goggles, and masks, and follow proper storage and disposal guidelines.
Check Digit Verification of cas no
The CAS Registry Mumber 67140-85-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,7,1,4 and 0 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 67140-85:
(7*6)+(6*7)+(5*1)+(4*4)+(3*0)+(2*8)+(1*5)=126
126 % 10 = 6
So 67140-85-6 is a valid CAS Registry Number.
67140-85-6Relevant academic research and scientific papers
Yu, Lei,Huang, Minhao,Xu, Tianfeng,Tong, Linjiang,Yan, Xiao-e,Zhang, Zhang,Xu, Yong,Yun, Caihong,Xie, Hua,Ding, Ke,Lu, Xiaoyun
, p. 1107 - 1117 (2017)
Structural optimization of pyrido[2,3-d]pyrimidin-7-ones was conducted to yield a series of new selective EGFRT790Minhibitors with improved pharmacokinetic properties. One of the most promising compound 9s potently suppressed EGFRL858R/T790Mkinase and inhibited the proliferation of H1975?cells with IC50values of 2.0?nM and 40?nM, respectively. The compound dose-dependently induced reduction of the phosphorylation of EGFR and downstream activation of ERK in NCI[sbnd]H1975?cells. It also exhibited moderate plasma exposure after oral administration and an oral bioavailability value of 16%. Compound 9s may serve as a promising lead compound for further drug discovery overcoming the acquired resistance of non-small cell lung cancer (NSCLC) patients.
