67170-60-9

Usage

Uses

Used in Pharmaceutical Research:
2,3-Pyrazinedicarbonitrile, 5-(4-methoxyphenyl)is used as a building block for the development of new pharmaceutical compounds due to its unique structure and potential for functionalization.
Used in Organic Synthesis:
2,3-Pyrazinedicarbonitrile, 5-(4-methoxyphenyl)is used as a key intermediate in the synthesis of various organic compounds, taking advantage of its reactive nitrile group and the presence of the pyrazine ring.
Used in Medicinal Chemistry:
2,3-Pyrazinedicarbonitrile, 5-(4-methoxyphenyl)is used as a starting material for the design and synthesis of novel drug candidates, leveraging its structural features to create molecules with desired biological activities.
Used in Material Science:
2,3-Pyrazinedicarbonitrile, 5-(4-methoxyphenyl)is used as a component in the development of new materials with tailored properties, such as in the creation of advanced polymers or other composite materials.
Used in Chemical Engineering:
2,3-Pyrazinedicarbonitrile, 5-(4-methoxyphenyl)is used in the engineering of chemical processes, potentially as a catalyst or in the synthesis of other valuable chemical products.

Upstream product

• 637-69-4 4-Methoxystyrene 
• 28321-79-1 diiminosuccinonitrile 
• 1076-95-5 p-methoxyphenylglyoxal 
• 1187-42-4 diaminomaleonitrile 
• 37494-42-1 5-(4-methoxy-phenyl)-1,4,5,6-tetrahydro-pyrazine-2,3-dicarbonitrile 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 59574-37-7 2-amino-3-(4-methoxybenzylideneamino)maleonitrile 
• 88549-04-6 2-amino-3-<2-(p-methoxyphenyl)aziridin-1-yl>maleonitrile 
• 54848-44-1 1,2-diamino-1,2-dicyanoethylene 

Downstream Products

• 80356-94-1 5-(4-Methoxy-phenyl)-pyrazine-2,3-dicarboxylic acid diamide 
• 80356-87-2 5-(4-Methoxy-phenyl)-pyrazine-2,3-dicarboxylic acid dimethyl ester 
• 80356-80-5 5-(4-Methoxy-phenyl)-pyrazine-2,3-dicarboxylic acid 

Relevant academic research and scientific papers

Iodine-mediated oxidative annulation for one-pot synthesis of pyrazines and quinoxalines using a multipathway coupled domino strategy

An efficient iodine-mediated oxidative annulation of aryl acetylenes-arylethenes-aromatic ketones with 1,2-diamines for the synthesis of pyrazines and regioselective synthesis of quinoxalines is presented. A multipathway coupled domino approach has been developed for the one-pot synthesis of 1,4-diazines with high functional group compatibility.

Hydrogen Cyanide Chemistry. 9. Cycloaddition Reactions and Nitrenium Ion Type Reactivity of Diiminosuccinonitrile

Cycloaddition reactions of diiminosuccinonitrile (DISN) with nucleophilic olefins yield a variety of products including cycloadducts and aziridines.All of the products derived from 1,3-dienes, styrene, para-substituted styrenes, cycloheptatriene, norbornene, and norbornadiene can be accounted for by rearrangements of a common intermediate, zwitterionic aziridinium ion.We introduce the concept of reverse polarization and propose that DISN is a latent nitrenium ion source (isoelectronic with carbenes) and that reverse polarization of one of the >C=N bonds of DISNis responsible for the observed reactions.Comments are made on reverse polarization of other >C=X bonds, and facile 1,1-cycloreversion of aziridines is also reported.

Structure-activity Relationship of Herbicidal 2,3-Dicyano-5-Substituted Pyrazines

Sixty six 2,3-dicyano-5-substituted pyrazines were synthesized and their herbicidal activities against barnyard grass were measured in pot tests to clarify the relationship between chemical structure and activity.The activity of 59 derivatives was related parabolically to the hydrophobic substituent parameter at the 5-position of the pyrazine ring.