671776-55-9Relevant academic research and scientific papers
Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases
Vonnussbaum, Franz,Li, Volkhart M.-J.,Allerheiligen, Swen,Anlauf, Sonja,B?rfacker, Lars,Bechem, Martin,Delbeck, Martina,Fitzgerald, Mary F.,Gerisch, Michael,Gielen-Haertwig, Heike,Haning, Helmut,Karthaus, Dagmar,Lang, Dieter,Lustig, Klemens,Meibom, Daniel,Mittendorf, Joachim,Rosentreter, Ulrich,Sch?fer, Martina,Sch?fer, Stefan,Schamberger, Jens,Telan, Leila A.,Tersteegen, Adrian
supporting information, p. 1163 - 1173 (2015/07/07)
Human neutrophil elastase (HNE) is a key protease for matrix degradation. High HNE activity is observed in inflammatory diseases. Accordingly, HNE is a potential target for the treatment of pulmonary diseases such as chronic obstructive pulmonary disease
HETEROCYCLIC DERIVATIVES
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Page/Page column 33-34, (2010/02/13)
The invention relates to novel heterocyclic derivatives, processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction and heart failure development.
1,4-DIARYL-DIHYDROPYRIMIDIN-2-ONES AND THEIR USE AS HUMAN NEUTROPHIL ELASTASE INHIBITORS
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Page/Page column 48, (2010/02/13)
The invention relates to novel heterocyclic derivatives of the general formula (I), processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myoca
