671780-69-1

Upstream product

• 79839-49-9 2-bromoisophthalaldehyde 
• 135590-51-1 1,3-bis(dibromomethyl)-2-bromobenzene 
• 156641-98-4 (6-methoxy-2-naphthalene)boronic acid 

Downstream Products

• 671780-70-4 2-methoxy-6-(2,6-divinylphenyl)naphthalene 
• 678996-94-6 2-(2,6-bis{2-methoxyvinyl}phenyl)-6-methoxynaphthalene 
• 917079-41-5 13C₂-2-methoxy-6-(2,6-divinylphenyl)naphthalene 
• 57303-99-8 7,8-Dihydroxybenzo[a]pyrene 
• 57404-88-3 (-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene 
• 65199-11-3 benzo[a]pyren-7,8-dione 
• 13345-26-1 7-hydroxy benzopyrene 

Relevant academic research and scientific papers

Synthesis of 13C2-benzo[a]pyrene and its 7,8-dihydrodiol and 7,8-dione implicated as carcinogenic metabolites

Synthesis of the 13C2-labelled analogues of the carcinogenic polycyclic aromatic hydrocarbon benzo[a]pyrene and its active metabolites is described. The method entails Pd-catalyzed Suzuki-Miyaura coupling of a naphthalene boronic aci

Synthesis of the o-Quinones and Other Oxidized Metabolites of Polycyclic Aromatic Hydrocarbons Implicated in Carcinogenesis

Efficient new syntheses of the o-quinone derivatives of benzo[a]pyrene (BPQ), 7,12-dimethylbenz-[a] anthracene (DMBAQ), and benz[a]anthracene (BAQ), implicated as active carcinogenic metabolites of the parent polycyclic aromatic hydrocarbons (PAHs), are reported. These PAH quinones also serve as starting compounds for the synthesis of the other active metabolites of these PAHs thought to be involved in their mechanism(s) of carcinogenesis. The latter include the corresponding o-catechols, trans-dihydrodiols, and the corresponding anti- and syn-diol epoxides.