671810-18-7

Upstream product

• 671810-16-5 4,5-O-cyclohexylidine perazidonebramine 
• 671810-15-4 perazidonebramine 
• 671810-17-6 4'-O-benzyl-4,5-O-cyclohexylidine perazidonebramine 

Downstream Products

• 671810-19-8 6-O-benzyloxymethoxy-4'-O-benzyl perazidonebramine 
• 671810-20-1 5-O-[(2R)-glycidyl]-6-O-benzyloxymethoxy-4'-O-benzyl perazidonebramine 

Relevant academic research and scientific papers

Dimeric aminoglycosides as antibiotics

Double duty: Dimeric aminoglycoside antibiotics were designed by linking neamine or nebramine cores with various tethers differing in length and composition. The resulting dimeric aminoglycosides displayed high affinity for the 16S A site of ribosomal RNA (a representation of the complex is shown here) and were effective against various aminoglycoside-resistant bacterial strains.

Aminoglycoside antibiotics as novel anti-infective agents

This invention relates to novel aminoglycoside compounds having antibacterial and anti-infective activity and to pharmaceutical compositions, methods of making and methods of treatment employing the same.