671817-79-1

Basic information

• Product Name: Benzenesulfonamide, 2-methoxy-5-[2-[(phenylmethyl)amino]propyl]-, monohydrochloride
• CAS NO: 671817-79-1
• Molecular Formula: C17H22N2O3S.ClH
• Molecular Weight: 370.9
• Mol File: 671817-79-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzenesulfonamide, 2-methoxy-5-[2-[(phenylmethyl)amino]propyl]-, monohydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonamide, 2-methoxy-5-[2-[(phenylmethyl)amino]propyl]-, monohydrochloride(671817-79-1)
• EPA Substance Registry System: Benzenesulfonamide, 2-methoxy-5-[2-[(phenylmethyl)amino]propyl]-, monohydrochloride(671817-79-1)

Safety Data

• Hazardous Substances Data: 671817-79-1(Hazardous Substances Data)

Upstream product

• 116091-63-5 2-methoxy-5-(2-oxopropyl)benzenesulfonamide 
• 100-46-9 benzylamine 

Relevant articles and documents

BENZENESULPHONAMIDES AND PROCESS FOR THEIR PREPARATION

New process for industrial preparation of R-(-)-tamsulosine HCl of formula (I). In this process (R,S)-5-[2-(N-benzyl-amino)-propyl]-2-methoxy-benzenesulphonamide of formula (I), acid addition salts and enantiomers thereof and R-5-[2-[N-(2-ethoxy-phenoxy)-ethyl]-N-benzyl]-amino]-propyl-2-methoxy-benzenesulphonamide of formula (III) are new intermediates. R-(-)-tamsulosine HCl of formula (I) is prepared by reacting the secondary benzylamine of formula (II) with an alkylating agent to R-5-[2-[N-(2-ethoxy-phenoxy)-ethyl]-N-benzyl]-amino]-propyl-2-methoxy-benzenesulphonamide of formula (III), the benzyl protecting group is removed and then HCl salt is formed. The optically active compound of formula (II) is prepared by reductive condensation of (4-methoxy-3-sulphamoyl-phenyl)-acetone and benzylamine and the obtained racemic compound is optically resolved by chiral acid.