671818-99-8Relevant academic research and scientific papers
Identification of a potent and selective non-basic cathepsin K inhibitor
Li, Chun Sing,Deschenes, Denis,Desmarais, Sylvie,Falgueyret, Jean-Pierre,Gauthier, Jacques Yves,Kimmel, Donald B.,Leger, Serge,Masse, Frederic,McGrath, Mary E.,McKay, Daniel J.,Percival, M. David,Riendeau, Denis,Rodan, Sevgi B.,Therien, Michel,Truong, Vouy-Linh,Wesolowski, Gregg,Zamboni, Robert,Black, W. Cameron
, p. 1985 - 1989 (2006)
Based on our previous study with trifluoroethylamine as a P2-P3 amide isostere of cathepsin K inhibitor, further optimization led to identification of compound 22 (L-873724) as a potent and selective non-basic cathepsin K inhibitor. This compound showed e
