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Usage

Uses

Used in Pharmaceutical Industry:
1-(4-Ethylphenoxy)-3-(isopropylamino)-2-propanol is used as a beta-blocking agent for the treatment of hypertension, angina, and certain arrhythmias. Its application is based on its ability to slow down the heart rate and reduce the force of heart contractions, which in turn lowers blood pressure and improves blood flow.
Additionally, due to the presence of the isopropylamino group, it is also used as a treatment for glaucoma, as it can help reduce intraocular pressure.

Upstream product

• 123-07-9 4-Ethylphenol 
• 75-31-0 isopropylamine 
• 106-89-8 epichlorohydrin 

Relevant academic research and scientific papers

Cardioselectivity as a function of molecular structure in β-adrenoceptor blocking agents of the 1-(para-substituted aryloxy)-3-(isopropylamino) propan-2-ol type

The relationship between molecular structure and cardioselectivity is described in the 1-(para-substituted aryloxy)-3-(isopropylamino)propan-2-ol type of β-adrenoceptor blocking agents. Cardioselectivity in the aforementioned series requires that the aromatic substitution in the position para to the amino alcohol side chain will have a minimal linear length of 5.0 A. Highest cardioselectivity is obtained when this para substituent is a rigid group coplanar with the aromatic ring. This may result from steric hindrance for binding at the β2-adrenoceptor subtype which does not occur in the β1 subtype. Evidence in favor of this suggestion was obtained by the finding that the trans isomer of 1-[4-(1-propenyl)-2-methoxyphenoxy]-3-(isopropylamino)propan-2-ol is cardioselective (β1/β2=25), whereas the cis isomer is β2 selective (β1/β2=0.1).