672-58-2

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
3-(Trifluoromethyl)benzenesulfonamide is utilized as a building block in the synthesis of various pharmaceuticals and agrochemicals due to its unique chemical structure and reactivity.
Used as a Catalyst in Organic Reactions:
In the field of organic chemistry, 3-(Trifluoromethyl)benzenesulfonamide is employed as a catalyst to facilitate and enhance the efficiency of certain reactions, contributing to the development of new chemical processes and compounds.
Used in Medicinal Chemistry:
3-(Trifluoromethyl)benzenesulfonamide is used as a reagent in the preparation of sulfonamides, a class of compounds that are significant in medicinal chemistry for their broad range of therapeutic applications.
Used as a Therapeutic Agent:
3-(Trifluoromethyl)benzenesulfonamide has demonstrated potential as a therapeutic agent, indicating its use in the development of new treatments for various medical conditions.
Used in Antifungal and Antibacterial Applications:
3-(Trifluoromethyl)benzenesulfonamide has shown promise as an antifungal and antibacterial agent, suggesting its use in the creation of new antimicrobial drugs to combat resistant strains of pathogens.

Upstream product

• 777-44-6 3-(Trifluoromethyl)benzenesulfonyl chloride 
• 17113-81-4 trimethyl(3-(trifluoromethyl)phenyl)stannane 
• 402-26-6 3-(trifluoromethyl)phenylmagnesium bromide 
• 98-16-8 3-trifluoromethylaniline 

Downstream Products

• 787-90-6 3-trifluoromethyl-benzenesulfonic acid-(trichlorophosphoranyliden-amide) 
• 102607-86-3 3-Trifluoromethyl-N-([(4-trifluoromethylphenyl)amino]carbonyl)benzenesulfonamide 
• 882423-09-8 N-methyl-3-(trifluoromethyl)benzenesulfonamide 
• 1176286-97-7 C₁₂H₁₄F₃NO₄S 
• 1254305-99-1 C₁₆H₈ClF₆N₃O₃S 

Relevant academic research and scientific papers

Design and synthesis of triazolopyrimidine acylsulfonamides as novel anti-mycobacterial leads acting through inhibition of acetohydroxyacid synthase

Novel triazolopyrimidine acylsulfonamides class of antimycobacterial agents, which are mycobacterial acetohydroxyacid synthase (AHAS) inhibitors were designed by hybridization of known AHAS inhibitors such as sulfonyl urea and triazolopyrimidine sulfonamides. This Letter describes the synthesis and SAR studies of this class of molecules by variation of two parts of the molecule, the phenyl and triazolopyrimidine rings. SAR study describes optimisation of enzyme potency, whole cell potency and evidence of mechanism of action.

Ruthenium trichloride catalyzed synthesis of 2,3-unsaturated-N-glycosides via Ferrier azaglycosylation

An efficient, economical and mild protocol for the synthesis of 2,3-unsaturated-N-glycosides has been developed using ruthenium(III) chloride. The Ferrier azaglycosylation of glycals with various N-nucleophiles such as sulfonamides, benzamides, carbamates and N-substituted sulfonamides proceeded smoothly to afford the corresponding 2,3-unsaturated-N-glycosides or ‘N-pseudoglycals’ in good yields (64–98%). High α-anomeric selectivity was observed with N-substituted sulfonamides such as N-benzyl or N-phenyl sulfonamides under similar conditions.

Mild and Efficient Synthesis of Aromatic Sulfonamides by in situ Preparation of the Corresponding Sulfonyl Isothiocyanates

A new reaction between chlorosulfonyl isocyanate (1) and trialkylstannyl-substituted arenes 2a-k, 7, 9 is described.It provides the aromatic sulfonyl isocyanates 3 or their derivatives, the sulfonamides 4a-j, the sulfonylcarbamates 5a-b, or sulfonylureas 6, respectively.The trialkylstannyl group as an efficient leaving group allows mild reaction conditions to be applied and unusual substitution patterns to be obtained, normally not accessible by electrophilic aromatic substitutions.Thus, sulfonamidation can be achieved in meta position to a trifluoromethyl group. Key words: Electrophilic aromatic substitution; sulfodestannalytion; isocyanates, sulfonyl, aromatic; sulfonyl compounds; trialkylarylstannanes, application of

DISSOCIATION OF SUBSTITUTED BENZENESULPHONAMIDES IN WATER, METHANOL AND ETHANOL

Thirteen monosubstituted arylsulphonamides (XC6H4SO2NH2) and two 3,4-disubstituted arylsulphonamides (X2C6H3SO2NH2) have been synthetized and their dissociation constants have been measured by potentiometric titration in water, methanol, and ethanol.The Hammett substitution dependences have been calculated for all the media, and changes in the reaction constants due to transition from water to alcohols are discussed in confrontation with analogous dependences of benzoic acids.The reaction constant ρ found in methanol is lower than that in water.The dissociation constants have been treated by the method of the principal components and by multiple linear regression.