67200-96-8Relevant academic research and scientific papers
Synthesis and Anti-Proliferative Activity of Novel Tricyclic Compounds Derived from 2-Substituted 1,3-Indandione
Abd-Elghaffar, H. S.,Al-Omar, M. A.,Amr, A. E.,El-Hashash, M. A.,Ibrahim, A. A.,Mohamed, S. F.,Nossier, E. S.
, p. 686 - 696 (2020)
Abstract: A new series of fused 1,3-indandione derivatives has been synthesized and evaluated for anti-proliferative activity. 2-Alkene-1,3-indandione derivatives have been used as the precursors of a number of tricyclic compounds. The latter have been te
Highly diastereoselective spiro-cyclopropanation of 2-arylidene-1,3-indanediones and dimethylsulfonium ylides
Huang, Jie,Lee, Kevin,Ma, Ping,Sun, Shaofa,Wang, Gangqiang,Wang, Jian,Wu, Yang,Xing, Yalan
supporting information, p. 18776 - 18780 (2021/10/26)
A highly diastereoselective spiro-cyclopropanation reaction of 2-arylidene-1,3-indanediones and dimethylsulfonium ylides has been developedviabase-induced annulation. This efficient and simple protocol features simple operations, mild conditions and excellent functional group compatibility. A variety of structurally interesting spiro-cyclopropanes were prepared in excellent yields and diastereomeric ratios (up to 97% yield and 20?:?1 dr). Also, ring expansion of the cyclopropanation product to quickly deliver a complex indeno[1,2-c]pyridazine structure showcased an interesting application of this method.
Benzylidine indane-1,3-diones: As novel urease inhibitors; synthesis, in vitro, and in silico studies
Bano, Bilquees,Kanwal,Khan, Khalid Mohammed,Begum, Farida,Lodhi, Muhammad Arif,Salar, Uzma,Khalil, Ruqaiya,Ul-Haq, Zaheer,Perveen, Shahnaz
, p. 658 - 671 (2018/09/29)
Current study deals with the evaluation of indane-1,3-dione based compounds as new class of urease inhibitors. For that purpose, benzylidine indane-1,3-diones (1–30) were synthesized and fully characterized by different spectroscopic techniques including
