67202-91-9Relevant academic research and scientific papers
Recognition of AMP, ADP and ATP through cooperative binding by Cu(II) and Zn(II) complexes containing urea and/or phenylboronic acid moieties
Carreira-Barral, Israel,Fernández-Pérez, Isabel,Mato-Iglesias, Marta,de Blas, Andrés,Platas-Iglesias, Carlos,Esteban-Gómez, David
, (2018)
We report a series of Cu(II) and Zn(II) complexes with different ligands containing a dipicolyl unit functionalized with urea groups that may contain or not a phenylboronic acid function. These complexes were designed for the recognition of phosphorylated anions through coordination to the metal ion reinforced by hydrogen bonds involving the anion and NH groups of urea. The complexes were isolated and several adducts with pyrophosphate were characterized using X-ray diffraction measurements. Coordination of one of the urea nitrogen atoms to the metal ion promoted the hydrolysis of the ligands containing 1,3-diphenylurea units, while ligands bearing 1-ethyl-3-phenylurea groups did not hydrolyze significantly at room temperature. Spectrophotometric titrations, combined with 1H and 31P NMR studies, were used in investigating the binding of phosphate, pyrophosphate (PPi), and nucleoside 5-polyphosphates (AMP, ADP, ATP, CMP, and UMP). The association constants determined in aqueous solution (pH 7.0, 0.1 M MOPS) point to a stronger association with PPi, ADP, and ATP as compared with the anions containing a single phosphate unit. The [CuL4]2+ complex shows important selectivity for pyrophosphate (PPi) over ADP and ATP.
Molecular recognition of sialic acid by lanthanide(III) complexes through cooperative two-site binding
Regueiro-Figueroa, Martin,Djanashvili, Kristina,Esteban-Gomez, David,Chauvin, Thomas,Toth, Eva,De Blas, Andres,Rodriguez-Blas, Teresa,Platas-Iglesias, Carlos
experimental part, p. 4212 - 4223 (2010/06/18)
Herein we report two new ligands, 1,4,7-tris(carboxymethyl)-10-[2- (dihydroxyboranyl)benzyl]-1,4,7,10-tetraazacyclododecane (L1) and 1,4,7-tris(carboxymethyl)-10-[3-(dihydroxyboranyl)benzyl]-1,4,7, 10-tetraazacyclododecane (L2), whic
Hydrolytically-Resistant Boron-Containing Therapeutics And Methods Of Use
-
Page/Page column 56, (2008/06/13)
Compositions and methods of use of boron derivatives, including benzoxaboroles, benzazaboroles and benzthiaboroles, as therapeutic agents for treatment of diseases caused by fungi, yeast, bacteria or viruses are disclosed, as well as methods for synthesis of said agents and compositions thereof.
Compounds for the Treatment of Periodontal Disease
-
Page/Page column 57, (2008/06/13)
Compounds, compositions and methods are provided which are useful in the treatment of periodontal disease.
Discovery of a new boron-containing antifungal agent, 5-fluoro-1,3-dihydro- 1-hydroxy-2,1-benzoxaborole (AN2690), for the potential treatment of onychomycosis
Baker, Stephen J.,Zhang, Yong-Kang,Akama, Tsutomu,Lau, Agnes,Zhou, Huchen,Hernandez, Vincent,Mao, Weimin,Alley,Sanders, Virginia,Plattner, Jacob J.
, p. 4447 - 4450 (2007/10/03)
A structure-activity relationship investigation for a more efficacious therapy to treat onychomycosis, a fungal infection of the toe and fingernails, led to the discovery of a boron-containing small molecule, 5-fluoro-1,3-dihydro- 1-hydroxy-2,1-benzoxaborole (AN2690), which is currently in clinical trials for onychomycosis topical treatment.
