67208-98-4

Upstream product

• 3978-80-1 Boc-Tyr-OH 
• 623-33-6 glycine ethyl ester hydrochloride 
• 459-73-4 GlyOEt*HCl 
• 1280225-74-2 C₂₄H₃₂N₂O₇ 

Downstream Products

• 957753-67-2 Boc-Tyr(4-cyanophenyl)-Gly-OEt 
• 82816-84-0 HCl*Phe-Tyr-Gly-Phe-Met-NH₂ 
• 40331-95-1 HCl*Phe-Tyr-Gly-Leu-Met-NH₂ 
• 82816-80-6 Boc-Phe-Tyr-Gly-Phe-Met-NH₂ 
• 3190-66-7 Boc-Phe-Tyr-Gly-OEt 
• 3423-93-6 Boc-Phe-Tyr-Gly 
• 4583-09-9 Boc-Phe-Tyr-Gly-Leu-Met-NH₂ 
• 74084-08-5 Boc-Phe-Val-Pro-Ile-Phe-Thr-Tyr-Gly-OEt 
• 74084-07-4 Boc-Val-Pro-Ile-Phe-Thr-Tyr-Gly-OEt 
• 74098-58-1 Boc-Ile-Phe-Thr-Tyr-Gly-OEt 
• 74084-06-3 Boc-Phe-Thr-Tyr-Gly-OEt 
• 74072-17-6 H-Thr-Tyr-Gly-OEt 
• 5845-66-9 3-(S)-(4-hydroxy-benzyl)-piperazine-2,5-dione 
• 70935-36-3 HCl*Tyr-Gly-OEt 

Relevant academic research and scientific papers

Synthesis of dipeptides from N-hydroxy-3-azaspiro[5,5]undecane-2,4-dione activated α-amino acids

A simple two step procedure for the synthesis of a dipeptide from N-hydroxy-3-azaspiro[5,5]undecane-2,4-dione (HO-ASUD) activated α-amino acids is described. In presence of DCC, N-hydroxy-3-azaspiro[5,5]undecane-2,4- dione readily esterifies the carboxylic acid group of all the N-protected amino acids to yield crystalline N-hydroxy-3-aza spiro[5,5]undecane-2,4-dione activated carboxy ester. The N-hydroxy-3-aza spiro[5,5]undecane-2,4-dione activated carboxy esters of N-protected amino acids readily condensed with other amino acids and gave a dipeptide. This new method is effective for the DCC coupling of a variety of chiral amino acids without loss of enantiomeric purity. Synthesis of fifteen dipeptides including the hitherto unreported Fmoc-l-Orn(Boc)-Val-OMe, Fmoc-l-Cys(trt)-Gly-OEt and Boc-l-Tyr-Gly-OEt is presented.

BENZOTRIAZOL-1-YL DIETHYL PHOSPHATE. A NEW CONVENIENT COUPLING REAGENT FOR THE SYNTHESIS OF AMIDES AND PEPTIDES.

Benzotriazol-1-yl diethyl phosphate is found to be a new convenient coupling reagent for the synthesis of amides and practically racemization-free peptides.

SYNTHESIS OF PENTAPEPTIDES RELATED BOTH TO SUBSTANCE P C-TERMINAL FRAGMENT AND MET-ENKEPHALIN

Six pentapeptide amides related both to Substance P C-terminal fragment and to Met-enkephalin have been synthesized.Syntheses were effected by coupling fragments 3 + 2 in solution.The DCC + HOBt method was used for synthesis of peptide fragments and final

Synthesis of porcine motilin via its sulfoxides

The protected segments corresponding to sequences 1-8 and 9-22 proposed for porcine motilin were synthesized mainly by the repetitive excess mixed anhydride (REMA) method.Mixed anhydride coupling of the segments gave protected motilin sulfoxide (Scheme).D