67217-41-8Relevant academic research and scientific papers
Asymmetric Umpolung Hydrogenation and Deuteration of Alkenes Catalyzed by Nickel
Guo, Siyu,Wang, Xiuhua,Zhou, Jianrong Steve
supporting information, p. 1204 - 1207 (2020/02/04)
Nickel-catalyzed asymmetric hydrogenation of several types of alkenes proceeds in high enantioselectivity, using acetic acid or water as the hydrogen source and indium powder as electron donor. The scope of alkenes herein include α,β-unsaturated esters, n
Highly enantioselective rhodium-catalyzed asymmetric 1,4-addition reactions of arylboronic acids to acyclic α,β-unsaturated compounds: The formal synthesis of (-)-indatraline
Wei, Wei-Ting,Yeh, Jiann-Yih,Kuo, Ting-Shen,Wu, Hsyueh-Liang
supporting information; experimental part, p. 11405 - 11409 (2011/11/12)
It's do or diene: Stable chiral bicyclo[2.2.1]diene ligands were synthesized from (-)-5-oxobornyl acetate and utilized in the asymmetric 1,4-addition reaction of arylboronic acids with acyclic α,β- unsaturated compounds. Low catalytic loading of the compl
New Homochiral Ligands Bearing Nonstereogenic Chirotopic Centers. Lithiated N,N′-Dialkylureas as Chiral Bases and Sterically Crowded Phosphines for Asymmetric Catalysis
Graf, Claus-Dieter,Malan, Christophe,Harms, Klaus,Knochel, Paul
, p. 5581 - 5588 (2007/10/03)
The synthesis of new homochiral pseudo-C2-symmetrical ligands of type 1 bearing a nonstereogenic chirotopic center is reported. Two such structural units are combined in the ureas 2 and 10, which proved to be useful for enantioselective deprotonation and alkylation of ketones (up to 88% ee). The monophosphine 3 induced a high enantiomeric excess in the Pd-catalyzed allylation of dimethyl malonate (up to 73% ee). Furthermore, we have shown that the achiral sterically crowded alkyl diphosphine 23 efficiently stabilized Pd(0) at high temperatures.
New chiral ligands with nonstereogenic chirotopic centers for asymmetric synthesis
Graf, Claus-Dieter,Malan, Christophe,Knochel, Paul
, p. 3014 - 3016 (2007/10/03)
Pseudo-C2-symmetrical ligands have been prepared efficiently: The attachment of the chiral alkyl group to the heteroatom (P or N) through a nonstereogenic, chirotopic carbon center facilitates their synthesis as the configuration at this carbon atom no longer needs to be controlled. Two such ligands were combined, for example, in the base 1, which is especially useful for asymmetric deprotonation of prochiral ketones [Eq. (a)].
