6722-06-1Relevant articles and documents
Thiourea-catalyzed enantioselective addition of indoles to pyrones: Alkaloid cores with quaternary carbons
Yeung, Charles S.,Ziegler, Robert E.,Porco, John A.,Jacobsen, Eric N.
supporting information, p. 13614 - 13617 (2015/02/05)
We report the development of a catalytic method for the enantioselective addition of indoles to pyrone-derived electrophiles. Arylpyrrolidino-derived thioureas catalyze the addition with high stereoselectivity in the presence of catalytic quantities of an achiral Bronsted acid. The indole-pyrone adducts feature a quaternary stereocenter and represent an unusual class of indolines bearing structural resemblance to the hybrid natural product pleiocarpamine.
Mild, efficient Fischer indole synthesis using 2,4,6-trichloro-1,3,5- triazine (TCT)
Siddalingamurthy, Eranna,Mahadevan, Kittappa M.,Masagalli, Jagadeesh N.,Harishkumar, Hosanagara N.
supporting information, p. 5591 - 5596 (2013/09/23)
Mild and efficient protocol for the Fischer indole synthesis using TCT has been described. TCT serves as a mild and inexpensive catalyst. Under these conditions several functional groups such as ester, cyano, sulfone, amides, and ethers are tolerated. By this method, many functionalized analytically pure indoles were prepared easily without the need of purification.