672296-58-1

Upstream product

• 327027-74-7 4-(tert-butyl-diphenyl-silanyloxy)-3-(4-methoxy-benzyloxy)-butyric acid methyl ester 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 815600-23-8 [2R]-2-(4-METHOXYPHENYL)-[1, 3] DIOXAN-4-YL methanol 
• 159801-08-8 methyl (3R)-4-(tert-butyldiphenylsilyloxy)-3-hydroxybutanoate 

Downstream Products

• 327027-75-8 (E)-(R)-6-(tert-Butyl-diphenyl-silanyloxy)-5-(4-methoxy-benzyloxy)-hex-2-enoic acid methyl ester 
• 672296-59-2 (3R, 4R, 6R)-7-(TERT-BUTYLDIPHENYLSILANYLOXY)-6-(4-METHOXYBENZYLOXY)-3-METHYLHEPT-L-EN-4-OL 
• 327027-71-4 (E)-(R)-6-(tert-Butyl-diphenyl-silanyloxy)-5-(4-methoxy-benzyloxy)-hex-2-enal 

Relevant academic research and scientific papers

Novel synthesis of stagonolide-F, putaminoxin and aspinolide-A

Novel synthesis of putaminoxin, stagonolide-F and aspinolide-A have been achieved by utilizing (S) and (R)- malic acid. The key feature of the synthetic strategy includes Horner-Wittig olefination, double bond reduction and Steglich esterification. Olefinic acid for putaminoxin and stagonolide-F was prepared from (S)-malic acid whereas olefinic acid for aspinolide-A was prepared from (R)-malic acid and olefinic alcohols for putaminoxin, stagonolide-F and aspinolide-A were prepared by using Brown's asymmetric allylboration.

Synthesis of the macrocyclic core of laulimalide

equation presented A stereoselective synthesis of 3, corresponding to the fully functionalized macrocyclic core of the novel microtubule-stabilizing agent, laulimalide, has been completed. Efficient macrolactonization was achieved by a Mitsunobu reaction,