672309-94-3

Basic information

• Product Name: (R)-2-CBZ-AMINO-BUTANE-1,4-DIOL
• Synonyms: (R)-BENZYL 1,4-DIHYDROXYBUTAN-2-YLCARBAMATE;(R)-2-Cbz-aminobutane-1,4-diol;(R)-(3-Hydroxy-1-hydroxymethylpropyl)carbamic acid benzyl ester;REF DUPL: (R)-2-Cbz-amino-butane-1,4-diol;Carbamic acid, [(1R)-3-hydroxy-1-(hydroxymethyl)propyl]-, phenylmethyl ester (9CI);(R)-(+)-2-(Cbz-amino)-1,4-butanediol
• CAS NO: 672309-94-3
• Molecular Formula: C₁₂H₁₇NO₄
• Molecular Weight: 239.27
• Mol File: 672309-94-3.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 461 °C at 760 mmHg
• Flash Point: 232.6 °C
• Appearance: /
• Density: 1.22 g/cm³
• Vapor Pressure: 2.71E-09mmHg at 25°C
• Refractive Index: 1.553
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (R)-2-CBZ-AMINO-BUTANE-1,4-DIOL(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-CBZ-AMINO-BUTANE-1,4-DIOL(672309-94-3)
• EPA Substance Registry System: (R)-2-CBZ-AMINO-BUTANE-1,4-DIOL(672309-94-3)

Safety Data

• Hazardous Substances Data: 672309-94-3(Hazardous Substances Data)

Usage

General Description

(R)-2-CBZ-AMINO-BUTANE-1,4-DIOL is a chemical compound that is commonly used as a reagent in chemical synthesis. It is a diol, containing two hydroxyl groups (-OH) and an amino group (NH2), and is protected with a carbamate group (CBZ). (R)-2-CBZ-AMINO-BUTANE-1,4-DIOL is often used in the synthesis of peptides and other organic molecules due to its ability to act as a chiral building block. The chiral nature of (R)-2-CBZ-AMINO-BUTANE-1,4-DIOL allows for the creation of enantiomerically pure compounds, which is important in the pharmaceutical and chemical industries for the production of drugs and other biologically active molecules.

InChI:InChI=1/C12H17NO4/c14-7-6-11(8-15)13-12(16)17-9-10-4-2-1-3-5-10/h1-5,11,14-15H,6-9H2,(H,13,16)/t11-/m1/s1

Upstream product

• 78663-07-7 N-(benzyloxycarbonyl)-D-aspartic acid 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 655785-24-3 (R)-2-(benzyloxycarbonylamino)-1,4-dimethanesulfonyloxybutane 

Relevant articles and documents

Preparation method of ceftobiprole intermediate (R)-1-benzyl-3-aminopyrrolidine

The invention discloses a preparation method of a ceftobiprole intermediate, namely (R)-1-benzyl-3-aminopyrrolidine. The preparation method specifically comprises the following steps: with D-asparticacid as an initial raw material, carrying out amino protection, esterification, reduction, bromination cyclization and 3-amino protection removal successively to obtain (R)-1-benzyl-3-aminopyrrolidine. According to the method, the defects that raw materials for preparing (R)-1-benzyl-3-aminopyrrolidine are expensive, high temperature and high pressure are needed, precious metal is used for catalysis and the like in the prior art are overcome. All the materials used in the invention are cheap and easily available, so cost is low; and reactions can be carried out at normal temperature, so energyconsumption is low, industrial production is facilitated, and pollution is small.