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Upstream product

• 90664-24-7 1-(3-Benzyloxy-5-methoxyphenyl)-2-(2,5-dibenzyloxy-4-methoxyphenyl)-3,3-dimethoxy-1-propanon 
• 90664-19-0 1-(3-Benzyloxy-5-methoxyphenyl)-3-(2,5-dibenzyloxy-4-methoxyphenyl)-2-propen-1-on 
• 97242-31-4 2,5-di(3-acetoxy-5-methoxybenzoyloxy)-4-methoxybenzyl bromide 
• 90664-28-1 1-(3-Benzyloxy-5-methoxyphenyl)-2-(2,5-dibenzyloxy-4-methoxyphenyl)-1-ethanon 
• 97242-33-6 3-(chlorocarbonyl)-5-methoxyphenyl acetate 
• 97242-30-3 3-acetoxy-5-methoxybenzoic acid 
• 19520-75-3 3-hydroxy-5-methoxybenzoic acid 
• 7417-68-7 2,5-dihydroxy-4-methoxytoluene 

Relevant academic research and scientific papers

Natural Benzofurans. Synthesis of Moracin A and B

2-(3,5-Dihydroxyphenyl)-4,6-dimethoxybenzofuran (Moracin A) and 2-(3-hydroxy-5-methoxyphenyl)-5-hydroxy-6-methoxybenzofuran (Moracin B), phytoalexins isolated from diseased mulberry have been synthesized by short routes in which the benzofuran heterocyclic system is formed by an intramolecular Wittig reaction.

A Practical Method for the Preparation of 2-Arylbenzofurans and the Synthesis of Moracin A and B

Oxidative rearrangement of 2-benzyloxychalcones 2 with Tl(NO3)3 in methanol to 1,2-diaryl-3,3-dimethoxy-1-propanones 3, alkaline degradation to aryl 2-benzyloxybenzyl ketones 4, debenzylation, and ring closure gave 2-arylbenzofurans 1.In this way moracin A and B (1a, b), further 2-(2,4-dihydroxyphenyl)-5,6-dimethoxybenzofuran (1c) were synthesized.The latter was not identical with a substance isolated from Myroxylon balsamum for which structure 1c was claimed.