6726-68-7

Upstream product

• 108-24-7 acetic anhydride 
• 6726-49-4 3,4-dimethyl-pyrazolo[5,1-c][1,2,4]triazine 

Downstream Products

• 1113032-92-0 (Z)-1-{4-benzylidene-3-methylpyrazolo[5,1-c][1,2,4]triazin-6(4H)-yl}ethanone 
• 1113033-10-5 1-{4-(diphenylmethylene)-3-methylpyrazolo[5,1-c][1,2,4]triazin-6(4H)-yl}ethanone 
• 1113033-01-4 (Z)-1-{4-(4-methoxybenzylidene)-3-methylpyrazolo[5,1-c][1,2,4]triazin-6(4H)-yl}ethanone 
• 1113033-37-6 C₂₃H₂₂N₄O 
• 1113033-40-1 C₂₁H₁₆F₂N₄O 

Relevant academic research and scientific papers

Structural studies on bioactive compounds. 1 Heck reactions on 4-methylenepyrazolo[5,1-c][1,2,4]triazines

1-(3-Methyl-4-methylenepyrazolo[5,1-c][1,2,4]triazin-6(4H-yl)ethanone 9a and its 7-methyl- 9b and 7-phenylderivative 9c undergo Heck coupling to afford (Z)-1-{4-benzylidene-3-methylpyrazolo[5,1-c][1,2,4]triazin-6(4H)- yl}ethanones 10a-c and substituted benzylidene analogues 10d-m as the major geometrical isomers in low yields. The most potent agent in a human tumour screen in vitro was 10b (mean GI50 value 4.9 mM in a panel of 60 human cancer cell lines), with evidence of selective action against colon KM12 (GI50 0.02 mM) and breast MCF-7 tumour cell lines (GI501.35 mM).