67262-53-7Relevant academic research and scientific papers
Atropisomeric amides: Stereoselective enolate chemistry and enantioselective synthesis via a new SmI2-mediated reduction
Hughes, Adam D.,Price, David A.,Simpkins, Nigel S.
, p. 1295 - 1304 (2007/10/03)
The use of certain types of atropisomeric amides, incorporating an N-MEM-ortho-tert-bityariume group, for stereoselective reactions, has been explored. Enolate reactions of these systems are highly diastereocontrolled, and enantiomerically enriched starting materials can be obtained, starting from lactic acid, via a new SmI2 mediated reduction process.
Synthesis and local anesthetic properties of secondary alkoxyalkylaminoacylanilides
Kronberg,Leard,Meymaris,Takman
, p. 595 - 600,597, 598 (2007/10/15)
Nineteen secondary alkoxyalkylaminoacylanilides were prepared. They were weaker bases and were more hydrophilic than the corresponding analogs lacking the ether function. In 2% solution, these compounds blocked the rat sciatic nerve in vivo after relative
