67263-23-4Relevant academic research and scientific papers
Preparation of benzimidazole N-oxides by a two-step continuous flow process
Politano, Fabrizio,Buján, Elba I.,Leadbeater, Nicholas E.
, p. 952 - 957 (2016)
A continuous flow process for the synthesis of nitrobenzimidazole N-oxides from 2,6-dinitrochlorobenzene and amines or amino acids is reported. The process, performed in a two-step sequence, is faster than previously reported batch processes and avoids so
Using experimental and computational approaches to probe an unusual carbon-carbon bond cleavage observed in the synthesis of benzimidazole: N -oxides
Politano, Fabrizio,Sandoval, Arturo León,Uranga, Jorge G.,Buján, Elba I.,Leadbeater, Nicholas E.
supporting information, p. 208 - 215 (2021/01/14)
Experimental and computational studies have been performed in order to investigate an unusual carbon-carbon bond cleavage that occurs in the preparation of certain benzimidazole N-oxides from anilines. The key factor determining the outcome of the reactio
The influence of steric effects on the kinetics and mechanism of SNAr reactions of 1-phenoxy-nitrobenzenes with aliphatic primary amines in acetonitrile
Isanbor, Chukwuemeka
, (2017/09/30)
Rate constants are reported for the reactions of 1-phenoxy-dinitrobenzenes, 3, 1-phenoxy-dinitrotrifluoromethylbenzenes, 4, with n-propylamine, and 1-methylheptylamine in acetonitrile as solvent. The results are compared with results reported previously f
A simple synthesis of benzimidazole N-oxides from 2-nitroaniline derivatives - Scope and limitations
Bujan, Elba I.,Salum, Maria Laura
, p. 1322 - 1327 (2007/10/03)
Several benzimidazole N-oxide derivatives were synthesized in very good yield by heating at reflux the corresponding N-alkyl-2-nitroaniline derivative with NaOH in 60% 1,4-dioxane-water. The effect of substituents on the aromatic ring and amino group on t
