67264-21-5Relevant academic research and scientific papers
Synthesis and radiofluorination of iodophenyl esters as tool for the traceless staudinger ligation
Pretze, Marc,Flemming, Anke,Koeckerling, Martin,Mamata, Constantin
, p. 1128 - 1136 (2011/01/09)
A new synthetic pathway for the preparation of ω-functionalized 2-iodophenyl esters as starting materials for the synthesis of substituted phosphanes is described. A radiolabeling of these esters with fluorine-18 has led to building blocks which were reacted with HPPh2 in a Pd-catalyzed P-C cross coupling to establish new phosphanes. These compounds can be applied as mild and bioorthogonal radiolabeling agents by means of the traceless Staudinger ligation. A route to access this class of compounds has been established.
