67271-66-3

Usage

Uses

Used in Pharmaceutical Synthesis:
2-Chloroacetoacetamide is used as an intermediate in the production of drugs for its role in the synthesis of various pharmaceutical compounds.
Used in Organic Chemistry:
It serves as a reagent in organic chemistry, facilitating various chemical reactions and processes.
Used in Agriculture:
2-Chloroacetoacetamide is used as a herbicide and pesticide, helping to control unwanted plant and pest growth in agricultural settings.
Used in Anticancer Therapy:
2-chloroacetoacetamide is used as a potential candidate for anticancer therapy due to its ability to inhibit the enzyme thioredoxin reductase, which plays a role in cancer cell survival and proliferation.

InChI:InChI=1/C4H6ClNO2/c1-2(7)3(5)4(6)8/h3H,1H3,(H2,6,8)

Upstream product

• 60930-76-9 2-chloro-3-oxobutanenitrile 
• 71739-37-2 α-Chlor-β-aminocrotonsaeurenitril 
• 5977-14-0 acetoacetamido 
• 4755-81-1 methyl 2-chloroacetoacetate 

Downstream Products

• 4866-00-6 4-methyl oxazole-5-carboxamide 
• 637001-82-2 C₁₆H₁₂ClF₄N₃O₅ 

Relevant academic research and scientific papers

METHOD FOR PREPARATION OF 2-CHLOROACETOACETIC ACID AMIDE AND ESTER

The invention discloses a method for the preparation of 2-chloro acetoacetic acid amide or ester by a reaction of acetoacetic acid amide or ester with trichloroisocyanuric acid in the presence of amylene and in the solvent acetone.

METHOD FOR PRODUCING 2-CHLOROACETOACETATE AMIDE

PROBLEM TO BE SOLVED: To provide a production method for obtaining 2-chloroacetoacetate amide in high yield. SOLUTION: A method for producing 2-chloroacetoacetate amide includes causing the reaction between acetoacetate amide and trichloroisocyanuric acid (where, the trichloroisocyanuric acid is 0.30 to 0.38 mol times the acetoacetate amide) to occur in an ethanol solvent; preferably, the ethanol content is 3 to 10 weight times the acetoacetate amide. SELECTED DRAWING: None COPYRIGHT: (C)2019,JPO&INPIT

2 - production of halo aceto acid amide (by machine translation)

A manufacturing method of [be] 2 - halo aceto acid amide. (1) formula [solution]The compound represented, solvents, halogenated by using a halogenating agent, (2) of formulaA compound represented by formula can be produced. [Drawing] no (by machine translation)

Preservation of aqueous systems with 2-chloro-3-oxobutyramide derivatives

There is disclosed methods and compositions for inhibiting or preventing the growth of microorganisms in aqueous systems wherein the growth is inhibited or prevented by the presence of an effective amount of a 2-chloro-3-oxobutyramide derivative.