67276-90-8Relevant academic research and scientific papers
Aziridine-2-carboxylic acid derivatives and its open-ring isomers as a novel PDIA1 inhibitors
Leite, Irena,Andrianov, Victor,Zelencova-Gopejenko, Diana,Loza, Einars,Kazhoka-Lapsa, Iveta,Domracheva, Ilona,Stoyak, Marta,Chlopicki, Stefan,Kalvins, Ivars
, p. 1086 - 1106 (2022/01/12)
[Figure not available: see fulltext.] Acyl derivatives of aziridine-2-carboxylic acid have been synthesized and tested as PDIA1 inhibitors. Calculations of charge value and distribution in aziridine ring system and some alkylating agents were performed. For the first time was found that acyl derivatives of aziridine-2-carboxylic acid are weak to moderately active PDIA1 inhibitors.
DERIVATIVES OF AZIRIDINE-1,2-DICARBOXYLIC ACID
Trapentsier, P. T.,Kalvin'sh, I. Ya.,Liepin'sh, E. E.,Lukevits, E. Ya.,Kauss, V. Ya.
, p. 891 - 895 (2007/10/02)
The corresponding esters and amides of aziridine-1,2-dicarboxylic acid were obtained by the reaction of esters and amides of aziridine-2-carboxylic acid with esters and amides of chlorocarbonic acid, isocyanates, and isothiocyanates.The reaction of 2-methoxycarbonylaziridine with diisocyanates and chlorides of the dicarboxylic acids leads to the formation of bisaziridines.
1-Aziridine carboxylic acid derivatives with immunostimulant activity
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, (2008/06/13)
2-Substituted-1-aziridine-carboxylic acid esters exhibiting immuno-stimulant activity and of the formula STR1 wherein X is a carbamoyl or alkoxycarbonyl radical, and R1 is an aliphatic hydrocarbon radical optionally substituted by halogen, alkoxy, amino, carbamoyloxy, cycloalkyl, hydroxyl, an imido or heterocyclic radical, cycloalkyl; or aryl, aralkyl, aryloxyalkyl or arylthioalkyl wherein the aryl moiety is optionally substituted by halogen, alkyl, alkoxy, hydroxyl, amino, nitro, cyano, acyl, carbalkoxy, thioalkyl, alkylsulphonyl, phenyl or trifluoromethyl. Counterparts where X is --CN and R1 is as above, except for ethyl, are also new.
