67280-45-9Relevant academic research and scientific papers
Allenes and Acetylenes. 28. On the Mechanism of Reduction of Propargylic Ethers and Acetates with Organocuprates
Sahlberg, Christer,Claesson, Alf
, p. 4120 - 4122 (2007/10/02)
The amounts of substitution and reduction products from the reaction of two types of propargylic methyl ethers and acetates with organocuprates were determined.The methyl ethers give rise to more of the reduction products than the acetates.It is shown that "reduced" allenes are formed by hydrolysis of an organometallic intermediate whereas "reduced" acetyles are formed mainly by another mechanistic pathway.The mechanisms of these reduction reactions are discussed in terms of stabilized, transient Cu(III)-intermediates and concerted β-hydride transfer in the formation of the acetylene.
Synthesis and monoamine oxidase inhibitory activities of α-allenic amines in vivo and in vitro. Different activities of two enantiomeric allenes
Sahlberg,Ross,Fagervall,Ask,Claesson
, p. 1036 - 1042 (2007/10/02)
A series of 15 α-allenic amines, including primary, secondary, and tertiary ones, was synthesized, partly by organocopper chemistry. Their ability to inhibit mouse and rat brain mitochondrial monoamine oxidase (MAO) in vivo and in vitro, respectively, was
Allenes and Acetylenes. XXIV. Synthesis of α-Allenic Amines by Organocuprate Reactions of Acetylenic Aminoethers
Sahlberg, Christer,Claesson, Alf
, p. 179 - 186 (2007/10/02)
Tertiary α-allenic amines 1a - d are formed in good yields in reactions of acetylenic aminoethers with an organocuprate reagent, derived from butylmagnesium bromide and 5-20percent of CuI, in tetrahydrofuran (THF) or THF-diethyl ether 3:1.The overall redu
