672906-67-1

Usage

Uses

Used in Pharmaceutical Industry:
(S)-N-METHYL-1-(4-FLUOROPHENYL)ETHYLAMINE is used as an intermediate or building block for the synthesis of various pharmaceuticals. Its unique structure allows it to be incorporated into a wide range of drug molecules, potentially leading to the development of new and more effective treatments for various diseases and conditions.
Used in Agrochemical Industry:
(S)-N-METHYL-1-(4-FLUOROPHENYL)ETHYLAMINE is also used as a building block in the synthesis of agrochemicals. Its incorporation into these compounds can lead to the development of new pesticides, herbicides, and other agricultural products that are more effective and environmentally friendly.
Used in Research and Development:
(S)-N-METHYL-1-(4-FLUOROPHENYL)ETHYLAMINE is used in research and development, particularly in the study of neurotransmitters and other biological processes. Its unique structure and potential pharmacological properties make it an interesting compound for researchers in the field of medicinal chemistry, who may use it to develop new drugs and therapies.
Used in Organic Chemistry:
(S)-N-METHYL-1-(4-FLUOROPHENYL)ETHYLAMINE is used as a building block in the synthesis of various organic compounds. Its versatility and unique structure make it a valuable component in the development of new organic molecules with a wide range of applications, from materials science to chemical engineering.

InChI:InChI=1/C9H12FN/c1-7(11-2)8-3-5-9(10)6-4-8/h3-7,11H,1-2H3/t7-/m0/s1

Upstream product

• 672906-84-2 C₂H₄O₂*C₉H₁₂FN 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 1227083-63-7 N-methyl-[1-(4'-fluorophenyl)ethylidene]amine 

Downstream Products

• 1145786-51-1 6-chloro-N-[(1S)-1-(4-fluorophenyl)ethyl]-N-methyl-3-pyridazinamine 

Relevant academic research and scientific papers

Tackling N-Alkyl Imines with 3d Metal Catalysis: Highly Enantioselective Iron-Catalyzed Synthesis of α-Chiral Amines

A readily activated iron alkyl precatalyst effectively catalyzes the highly enantioselective hydroboration of N-alkyl imines. Employing a chiral bis(oxazolinylmethylidene)isoindoline pincer ligand, the asymmetric reduction of various acyclic N-alkyl imines provided the corresponding α-chiral amines in excellent yields and with up to >99 % ee. The applicability of this base metal catalytic system was further demonstrated with the synthesis of the pharmaceuticals Fendiline and Tecalcet.

Direct Asymmetric Hydrogenation of N-Methyl and N-Alkyl Imines with an Ir(III)H Catalyst

A novel cationic [IrH(THF)(P,N)(imine)] [BArF] catalyst containing a P-stereogenic MaxPHOX ligand is described for the direct asymmetric hydrogenation of N-methyl and N-alkyl imines. This is the first catalytic system to attain high enantioselectivity (up to 94% ee) in this type of transformation. The labile tetrahydrofuran ligand allows for effective activation and reactivity, even at low temperatures. Density functional theory calculations allowed the rationalization of the stereochemical course of the reaction.

OPTICALLY ACTIVE 1-(FLUORO-,TRIFLUOROMETHYL-OR TRIFLUOROMETHOXY-SUBSTITUTED PHENYL)ALKYLAMINE N-MONOALKYL DERIVATIVES AND PROCESS FOR PRODUCING SAME

An optically active 1-(fluoro-, trifluoromethyl- or trifluoromethoxy-substituted phenyl)alkylamine N-monoalkyl derivative represented by the formula [4] is produced by a process including (a) reacting an optically active secondary amine, represented by th