672912-22-0Relevant articles and documents
Synthesis and Characterization of a Series of Orthogonally Protected l-Carnosine Derivatives
El-Dakdouki, Mohammad H.,Daouk, Nadine,Abdallah, Hiba
, p. 1 - 12 (2018/02/19)
l-Carnosine (β-alanyl-l-histidine) is an endogenous dipeptide that has been recognized for its broad spectrum of beneficial biological activities. However, the therapeutic utility of molecule has been hampered by its instability in human plasma (half-life
Mechanochemical Synthesis of Dipeptides Using Mg-Al Hydrotalcite as Activating Agent under Solvent-Free Reaction Conditions
Landeros, José M.,Juaristi, Eusebio
, p. 687 - 694 (2017/02/05)
Given the high demand for green and sustainable synthetic methods for the formation of amides and peptidic bonds, herein we report the efficient, solvent-free mechanochemical synthesis of dipeptides from N-protected amino acids and amino acid methyl ester
Synthesis of highly substituted imidazolidine-2,4-dione (Hydantoin) through Tf2O-mediated dual activation of Boc-protected dipeptidyl compounds
Liu, Hui,Yang, Zhimin,Pan, Zhengying
supporting information, p. 5902 - 5905 (2015/01/08)
Highly substituted chiral hydantoins were readily synthesized from simple dipeptides in a single step under mild conditions. This reaction proceeded through the dual activation of an amide and a tert-butyloxycarbonyl (Boc) protecting group by Tf2O-pyridine. This method was successfully applied in the preparation of a variety of biologically active compounds, including drug analogs and natural products.
Beyond azide-alkyne click reaction: Easy access to 18F-labelled compounds via nitrile oxide cycloadditions
Zlatopolskiy, Boris D.,Kandler, Rene,Kobus, Diana,Mottaghy, Felix M.,Neumaier, Bernd
supporting information; experimental part, p. 7134 - 7136 (2012/07/27)
Radiofluorinated 4-fluorobenzonitrile oxide and N-hydroxy-4- fluorobenzimidoyl chloride rapidly react with different alkenes and alkynes under mild conditions. These cycloadditions are suitable for the preparation of low-molecular weight radiopharmaceutic
Green synthesis of α,β- and β,β-dipeptides under solvent-free conditions
Hernandez, Jose G.,Juaristi, Eusebio
experimental part, p. 7107 - 7111 (2010/12/24)
The reactivity of N-tert-butyloxycarbonyl-N-carboxyanhydrides derived from β-alanine, (S)-β3-homophenylglycine, and (S)-β3-carboxyhomoglycine with different α- and β-amino ester hydrochlorides was examined under ball-milling activati
A new molecular scaffold for the formation of supramolecular peptide double helices: The crystallographic insight
Guha, Samit,Drew, Michael G. B.,Banerjee, Arindam
, p. 1347 - 1350 (2007/12/29)
A series of water-soluble synthetic dipeptides (1-3) with an N-terminally located β-alanine residue, β-alanyl-L-valine (1), β-alanyl-L- isoleucine (2), and β-alanyl-L-phenylalanine (3), form hydrogen-bonded supramolecular double helices with a pitch length of 1 nm, whereas the C-terminally positioned β-alanine containing dipeptide (4), L-phenylalanyl-β-alanine, does not form a supramolecular double helical structure. β-Ala-Xaa (Xaa = Val/lle/Phe) can be regarded as a new motif for the formation of supramolecular double helical structures in the solid state.
Synthesis and activity of HCO-Met-Leu-Phe-OMe analogues containing β-alanine or taurine at the central position
Giordano, Cesare,Lucente, Gino,Nalli, Marianna,Zecchini, Giampiero Pagani,Paradisi, Mario Paglialunga,Varani, Katia,Spisani, Susanna
, p. 1121 - 1130 (2007/10/03)
New synthetic analogues of the chemotactic N-formyltripeptide HCO-Met-Leu-Phe-OMe have been synthesized. The reported new models, namely Boc-Met-β-Ala-Phe-OMe (1), HCO-Met-β-Ala-Phe-OMe (2), Boc-Met-Tau-Phe-OMe (3), HCO-Met-Tau-Phe-OMe (4) and HCl·Met-Tau
