672949-77-8

Basic information

• Product Name: 2-BROMO-1-[3,4-DIHYDRO-2(1H)-ISOQUINOLINYL]-2,2-DIFLUORO-1-ETHANONE
• Synonyms: 2-BROMO-1-[3,4-DIHYDRO-2(1H)-ISOQUINOLINYL]-2,2-DIFLUORO-1-ETHANONE;2-bromo-2,2-difluoro-1-(1,2,3,4-tetrahydroisoquinolin-2-yl)ethan-1-one
• CAS NO: 672949-77-8
• Molecular Formula: C11H10BrF2NO
• Molecular Weight: 290.1
• Mol File: 672949-77-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-BROMO-1-[3,4-DIHYDRO-2(1H)-ISOQUINOLINYL]-2,2-DIFLUORO-1-ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-1-[3,4-DIHYDRO-2(1H)-ISOQUINOLINYL]-2,2-DIFLUORO-1-ETHANONE(672949-77-8)
• EPA Substance Registry System: 2-BROMO-1-[3,4-DIHYDRO-2(1H)-ISOQUINOLINYL]-2,2-DIFLUORO-1-ETHANONE(672949-77-8)

Safety Data

• Hazardous Substances Data: 672949-77-8(Hazardous Substances Data)

Upstream product

• 91-21-4 1,2,3,4-tetrahydroisoquinoline 
• 667-27-6 Ethyl bromodifluoroacetate 

Downstream Products

• 55649-51-9 2-(trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline 

Relevant articles and documents

Copper-Catalyzed Cross-Coupling of Arylacetylenes with Bromodifluoroacetamides

A copper-catalyzed radical difluoroalkylation of arylacetylenes with bromodifluoroamides has been developed. The reaction exhibits good functional group tolerance and allows access to a variety of substituted α-alkynyl-α,α-difluoroacetamides in moderate to good yields. The potential for scale-up reaction and products derivatization also makes this method attractive for practical applications. Preliminary mechanistic studies suggest that a radical reaction pathway might be involved in the catalytic system.

Efficient DBU accelerated synthesis of 18F-labelled trifluoroacetamides

Nucleophilic 18F-fluorination of bromodifluoromethyl derivatives was performed using [18F]Bu4NF in the presence of DBU (1,8-diazabicyclo[5.4.0]undec-7-ene). This novel procedure provided a diverse set of [18F]trifluoroacetamides in good to excellent radiochemical conversions. A mechanism where DBU acts as organomediator in this transformation is proposed.