672965-18-3

Upstream product

• 261360-71-8 N-tert-butoxycarbonyl-3-methoxy-L-phenylalanine 
• 672965-06-9 Acetic acid (1S,2S)-2-tert-butoxycarbonylamino-3-(3-methoxy-phenyl)-1-methylsulfanylcarbonyl-propyl ester 
• 672965-03-6 [3-methanesulfinyl-1-(3-methoxy-benzyl)-2-oxo-propyl]-carbamic acid tert-butyl ester 
• 184176-05-4 methyl (S)-2-((tert-butyloxycarbonyl)amino)-3-(3-methoxyphenyl)propanoate 
• 117918-23-7 (R)-3-tert-butoxycarbonyl-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid 

Downstream Products

• 1018831-85-0 C₃₃H₃₉ClN₄O₅S 

Relevant academic research and scientific papers

Structure-activity relationships of novel HIV-1 protease inhibitors containing the 3-amino-2-chlorobenzoyl-allophenylnorstatine structure

A series of peptidomimetic human immunodeficiency virus (HIV) protease inhibitors containing substituted allophenylnorstatine (Apns: (2S,3S)-3-amino-2-hydroxy-4-phenylbutyric acid) were designed and synthesized. From the structure-activity relationship of this series of compounds, SM-309515 was found to have potent antiviral activity against wild-type and resistant HIV-1s and to possess a desirable pharmacokinetic profile in dogs.

Structure-activity and structure-metabolism relationships of HIV protease inhibitors containing the 3-hydroxy-2-methylbenzoyl-allophenylnorstatine structure

A series of peptidomimetic human immunodeficiency virus (HIV) protease inhibitors containing substituted allophenylnorstatine [Apns: (2S,3S)-3-amino-2-hydroxy-4-phenylbutyric acid] were designed and synthesized. From the structure-metabolism relationship of this type of HIV protease inhibitors, the compounds having para substitution of the phenyl ring of Apns and/or 2,6-disubstitution of the P2′ benzylamine were found to be able to avoid the P2 phenol glucuronidation that occurs with SM-319777 (formerly named JE-2147, KNI-764); one of the main metabolic pathways of SM-319777. These new analogues, such as SM-322377, had more desirable pharmacokinetic profiles and more potent antiviral activity against not only wild type HIV-1 but also the multi-drug-resistant HIV-1 than SM-319777.