67319-76-0

Basic information

• Product Name: N-(4-AMINOBUTYL)IMIDAZOLE
• Synonyms: N-(4-AMINOBUTYL)IMIDAZOLE;1H-Imidazole-1-butanamine;4-Imidazol-1-yl-butylamine
• CAS NO: 67319-76-0
• Molecular Formula: C₇H₁₃N₃
• Molecular Weight: 139.2
• Mol File: 67319-76-0.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 302.4°C at 760 mmHg
• Flash Point: 136.7°C
• Appearance: /
• Density: 1.08g/cm³
• Vapor Pressure: 0.000991mmHg at 25°C
• Refractive Index: 1.552
• CAS DataBase Reference: N-(4-AMINOBUTYL)IMIDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-AMINOBUTYL)IMIDAZOLE(67319-76-0)
• EPA Substance Registry System: N-(4-AMINOBUTYL)IMIDAZOLE(67319-76-0)

Safety Data

• Hazardous Substances Data: 67319-76-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C7H13N3/c8-3-1-2-5-10-6-4-9-7-10/h4,6-7H,1-3,5,8H2

Upstream product

• 93668-30-5 2-[4-(1H-imidazol-1-yl)butyl]-1H-isoindole-1,3(2H)-dione 
• 72338-63-7 4-imidazol-1-ylbutyronitrile 

Downstream Products

• 90260-14-3 2-amino-N-[4-(1H-imidazol-1-yl)butyl]benzamide 
• 1178564-43-6 3-(1-methyl-1H-indol-3-yl)-4-(1-(4-(1H-imidazol-1-yl)butyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)-1-phenyl-1H-pyrrole-2,5-dione 
• 107962-04-9 N-<4-(1H-imidazol-1-yl)butyl>-6-<<2-bromo-4-(1-methylethyl)phenyl>amino>-3-pyridinecarboxamide 
• 88939-84-8 N-<4-(1H-imidazol-1-yl)butyl>-2-(1-methylethyl)-11-oxo-11H-pyrido<2,1-b>quinazoline-8-carboxamide 
• 107962-03-8 N-<4-(1H-imidazol-1-yl)butyl>-6-<(4-isopropylphenyl)-amino>-3-pyridinecarboxamide 
• 154965-43-2 Dithiophosphoric acid O-[(2R,3S,5R)-2-[[3-(4-imidazol-1-yl-butylcarbamoyl)-phenyl]-bis-(4-methoxy-phenyl)-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S,S'-diphenyl ester 
• 154965-39-6 3-[[(2R,3S,5R)-3-Hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethoxy]-bis-(4-methoxy-phenyl)-methyl]-N-(4-imidazol-1-yl-butyl)-benzamide 
• 110552-68-6 2-Amino-5-chloro-N-(4-imidazol-1-yl-butyl)-benzamide 
• 93668-23-6 4-Bromo-N-(4-imidazol-1-yl-butyl)-benzamide 
• 93668-22-5 3,4-Dichloro-N-[4-(1H-imidazol-1-yl)butyl]benzamide 

Relevant articles and documents

MODULATORS OF STIMULATOR OF INTERFERON GENES (STING)

The present invention relates to compounds of formula (I) and salts, stereoisomers, tautomers or N-oxides thereof that are useful as modulators of STING (Stimulator of Interferon Genes). The present invention further relates to the compounds of formula (I) for use as a medicament and to a pharmaceutical composition comprising said compounds.

The first potent inhibitors for human glutaminyl cyclase: Synthesis and structure-activity relationship

The first effective inhibitors for human glutaminyl cyclase (QC) are described. The structures are developed by applying a ligand-based optimization approach starting from imidazole. Screening of derivatives of that heterocycle led to compounds of the imidazol-1-yl-alkyl thiourea type as a lead scaffold. A library of thiourea derivatives was synthesized, resulting in an inhibitory improvement by 2 orders of magnitude, leading to 1-(3-(1H-imidazol-1-yl)propyl)- 3-(3,4-dimethoxyphenyl)thiourea as a potent inhibitor. Systematic exploitation of the scaffold revealed a strong impact on the inhibitory efficacy and resulted in the development of imidazole-propyl-thioamides as another new class of potent inhibitors. A flexible alignment of the most potent compounds of the thioamide and thiourea class and a QC substrate revealed a good match of characteristic features of the molecules, which suggests a similar binding mode of both inhibitors and the substrate to the active site of QC.

2-heteroaryl-alkyl-1H-benz[de]-isoquinoline-1,3(2H)-diones

This invention concerns novel 2-heteroarylalkyl-1H-benz[de]isoquinoline-1,3(2H)-diones which are useful as inhibitors of thromboxane synthetase and/or as hypotensive agents in the treatment of hypertension and myocardial ischemia.