67333-09-9

Usage

Uses

Used in Pharmaceutical Industry:
4-(2-Aminoethoxy)benzonitrile is used as an intermediate for the synthesis of various pharmaceuticals, contributing to the development of organic compounds with medicinal properties. Its presence in the production process makes it an important building block for creating effective and innovative drugs.
Used in Agrochemical Industry:
In the agrochemical industry, 4-(2-Aminoethoxy)benzonitrile is utilized as an intermediate for the synthesis of agrochemicals, playing a crucial role in the development of compounds that can enhance crop protection and yield.
Used in Organic Synthesis:
4-(2-Aminoethoxy)benzonitrile is employed as a key component in organic synthesis, where it aids in the creation of new chemical compounds with diverse properties. Its unique structure and functional groups make it a valuable asset in the synthesis of a wide range of organic compounds.
Used in the Development of Fine Chemicals:
4-(2-Aminoethoxy)benzonitrile is also used as an intermediate in the production of fine chemicals, which are high-purity chemicals used in various applications, including research, pharmaceuticals, and specialty industries. Its versatility and reactivity make it an essential component in the synthesis of these high-quality chemicals.

InChI:InChI=1/C9H10N2O/c10-5-6-12-9-3-1-8(7-11)2-4-9/h1-4H,5-6,10H2

Upstream product

• 919085-52-2 tert-butyl (2-(4-cyanophenoxy)ethyl)carbamate 
• 767-00-0 4-cyanophenol 
• 37142-39-5 4-(2-bromoethoxy)benzonitrile 

Downstream Products

• 1432616-05-1 3-((dimethylamino)methyl)-N-(2-(4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)phenoxy)ethyl)benzofuran-2-carboxamide 
• 1432630-83-5 (Z)-3-((dimethylamino)methyl)-N-(2-(4-(N'-hydroxycarbamimidoyl)phenoxy)ethyl)benzofuran-2-carboxamide 
• 1432617-12-3 N-(2-(4-cyanophenoxy)ethyl)-3-((dimethylamino)methyl)benzofuran-2-carboxamide 
• 111625-02-6 4-{2-[4-Cyano-5-methyl-4-(3,4,5-trimethoxy-phenyl)-hexylamino]-ethoxy}-benzonitrile 
• 138803-36-8 4-{2-[3-(6-Chloro-pyridazin-3-yloxy)-2-hydroxy-propylamino]-ethoxy}-benzonitrile 

Relevant academic research and scientific papers

Discovery of O-(3-carbamimidoylphenyl)-l-serine amides as matriptase inhibitors using a fragment-linking approach

Matriptase is a cell-surface trypsin-like serine protease of epithelial origin, which cleaves and activates proteins including hepatocyte growth factor/scatter factor and proteases such as uPA, which are involved in the progression of various cancers. Here we report a fragment-linking approach, which led to the discovery of O-(3-carbamimidoylphenyl)-l-serine amides as potent matriptase inhibitors. The co-crystal structure of one of the potent inhibitors, 6 in complex with matriptase catalytic domain validated the working hypothesis guiding the development of this congeneric series and revealed the structural basis for matriptase inhibition. Replacement of a naphthyl group in 6 with 2,4,6-tri-isopropyl phenyl resulted in 10 with improved matriptase inhibition, which exhibited significant primary tumor growth inhibition in a mouse model of prostate cancer. Compounds such as 10, identified using a fragment-linking approach, can be explored further to understand the role of matriptase as a drug target in cancer and inflammation.

COMPOUNDS AND METHODS TO INHIBIT HISTONE DEACETYLASE (HDAC) ENZYMES

The invention relates to compounds that inhibit histone deacetylase (HDAC) enzymes, the preparation of these compounds, the use of these compounds in the treatment of diseases or conditions ameliorated by inhibition of HDAC activity, and pharmaceutical co

Imidazole derivatives as therapeutic agents

Compounds of the formula I STR1 and pharmaceutically acceptable salts thereof in which R1 represents hydrogen, halo, cyano, cyanoalkyl, alkyl, alkoxy, phenoxy, phenyl, alkoxycarbonyl, --NR13 R14, --N(R15)SO2 R16, halogenated alkoxy, halogenated alkyl, arylalkoxy, hydroxy, phenylalkyl, alkoxycarbonylvinyl, --S(O)n R7, alkoxycarbonylalkyl, carboxyalkyl, --CONR11 R12 carbamoylvinyl, --OSO2 R21, 4,5-dihydrothiazol-2-yl, 4,4-dimethyl-2-oxazolin-2-yl or --NR60 R61 ; or R1 represents a group of formula --(O)z --L3 G wherein z equals 0 or 1, L3 represents a C1-4 alkylene chain, G represents a group of formula a), b), c), or d): a) --NR22 R23 ; b) --S(O)m R26 ; c) CONR27 R28 ; d) --OR29 ; R2 and R3 independently represent hydrogen, halo, alkyl, alkoxy, --NR13 R14, halogenated alkoxy, halogenated alkyl, hydroxy, --S(O)n R7 or --NR60 R61 ; L1 represents e) a bond, or f) alkylene, cycloalkylene or cycloalkylidene; T represents a bond or O, S, SO, SO2, a carbonyl group, or 1,3-dioxolan-2-ylidene; L2 represents alkylene, cycloalkylene, or cycloalkylidene; R6 represents hydrogen or alkyl (optionally substituted by alkoxycarbonyl or hydroxy); Q represents a C1-9 alkylene chain (optionally substituted by alkyl or hydroxy); and Y represents an optionally substituted imidazole ring; which are antiinflammatory, antiallergic and immunodulant agents. Compositions containing these compounds and processes to make them are also disclosed.