67334-40-1Relevant academic research and scientific papers
STEREOCHEMICAL ASPECTS OF THE FORMATION OF DIASTEREOISOMERIC 3-ACETYL-2-(POLYACETOXYALKYL)-5-PHENYL-2,3-DIHYDRO-1,3,4-OXADIAZOLES
Somogyi, Laszlo
, p. 19 - 30 (2007/10/02)
The synthesis of D- and L-3-acetyl-2-- and 3-acetyl-2--5-phenyl-2,3-dihydro-1,3,4-oxadiazoles via cyclisation of the corresponding (O-acetylating conditions is described.The stereochemical aspects of the formation of C-2 epimeric oxadiazolines are discussed on the basis of optical rotation and n.m.r. data.The acetylation of methylglyoxal bis(benzoylhydrazone) (8) was found to give diastereoisomeric 1,3,4-oxadiazolines (12a and 12b) insteadof the bis(acetylbenzoylhydrazone) 9 claimed in the literature.
