67340-75-4

Basic information

• Product Name: (7R,8R,9S,10R,13S,14S)-7-Benzylsulfanyl-10,13-dimethyl-1,6,7,8,9,10,11,12,13,14,15,16-dodecahydro-2H-cyclopenta[a]phenanthrene-3,17-dione
• Synonyms: (7R,8R,9S,10R,13S,14S)-7-Benzylsulfanyl-10,13-dimethyl-1,6,7,8,9,10,11,12,13,14,15,16-dodecahydro-2H-cyclopenta[a]phenanthrene-3,17-dione
• CAS NO: 67340-75-4
• Molecular Weight: 408.605
• Mol File: 67340-75-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (7R,8R,9S,10R,13S,14S)-7-Benzylsulfanyl-10,13-dimethyl-1,6,7,8,9,10,11,12,13,14,15,16-dodecahydro-2H-cyclopenta[a]phenanthrene-3,17-dione(CAS DataBase Reference)
• NIST Chemistry Reference: (7R,8R,9S,10R,13S,14S)-7-Benzylsulfanyl-10,13-dimethyl-1,6,7,8,9,10,11,12,13,14,15,16-dodecahydro-2H-cyclopenta[a]phenanthrene-3,17-dione(67340-75-4)
• EPA Substance Registry System: (7R,8R,9S,10R,13S,14S)-7-Benzylsulfanyl-10,13-dimethyl-1,6,7,8,9,10,11,12,13,14,15,16-dodecahydro-2H-cyclopenta[a]phenanthrene-3,17-dione(67340-75-4)

Safety Data

• Hazardous Substances Data: 67340-75-4(Hazardous Substances Data)

Upstream product

• 633-34-1 androst-4,6-diene-3,17-dione 
• 100-53-8 phenylmethanethiol 

Relevant articles and documents

7α-Substituted Derivatives of Androstenedione as Inhibitors of Estrogen Biosynthesis

In an effort to obtain more information on the structure-activity relationship among the 7α-(phenylthio)androstenedione inhibitors of the enzyme aromatase, a series of compounds containing both electron-donating and electron-withdrawing ring substituents was synthesized and tested for aromatase inhibitory activity.No linear correlation between substituent electronic effects and inhibitory activity was observed.The halogen-containing compounds, particularly 8, appeared to be quite potent inhibitors.The 125I analogue of 8 was synthesized in order to evaluate the possibility of side-chain elimination under the assay conditions.Approximately 90percent of -8 remainded intact for up to 1 h under assay conditions.