67345-22-6

Basic information

• Product Name: 2-[Bis(2-chloroethyl)amino]-4-(ethoxycarbonyl)tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide
• Synonyms: 2-[Bis(2-chloroethyl)amino]-4-(ethoxycarbonyl)tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide
• CAS NO: 67345-22-6
• Molecular Formula: C10H19 Cl2 N2 O4 P
• Molecular Weight: 333.1486
• Mol File: 67345-22-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 405°Cat760mmHg
• Flash Point: 198.8°C
• Appearance: /
• Density: 1.34g/cm³
• Vapor Pressure: 9.04E-07mmHg at 25°C
• Refractive Index: 1.505
• CAS DataBase Reference: 2-[Bis(2-chloroethyl)amino]-4-(ethoxycarbonyl)tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[Bis(2-chloroethyl)amino]-4-(ethoxycarbonyl)tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide(67345-22-6)
• EPA Substance Registry System: 2-[Bis(2-chloroethyl)amino]-4-(ethoxycarbonyl)tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide(67345-22-6)

Safety Data

• Hazardous Substances Data: 67345-22-6(Hazardous Substances Data)

Usage

General Description

2-[Bis(2-chloroethyl)amino]-4-(ethoxycarbonyl)tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide is a chemical compound used in chemotherapy to treat various types of cancer. It is a nitrogen mustard-based alkylating agent that is designed to damage the DNA of cancer cells, preventing their growth and division. 2-[Bis(2-chloroethyl)amino]-4-(ethoxycarbonyl)tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide is known for its cytotoxic and antitumor properties and is often used in combination with other cancer treatments to improve their effectiveness. However, it can also cause severe side effects such as bone marrow suppression and gastrointestinal toxicity. Due to its potent carcinogenic and mutagenic properties, proper handling and administration procedures are necessary to minimize the risk to healthcare workers and patients.

InChI:InChI=1/C10H19Cl2N2O4P/c1-2-17-10(15)9-3-8-18-19(16,13-9)14(6-4-11)7-5-12/h9H,2-8H2,1H3,(H,13,16)

Upstream product

• 127-88-8 N,N-di(2-chloroethyl)amidophosphoric acid dichloride 

Relevant articles and documents

Synthesis and antitumor evaluation of 4-ethoxycarbonyl cyclophosphamide analogs

4 Ethoxycarbonyl analogs of cyclophosphamide and its five-membered ring homolog were synthesized utilizing the cyclization method previously described. N,N Bis(2 chloroethyl) 4 ethoxycarbonyl 1,3,2 oxazaphospholidin 2 amine 2 oxide demonstrated activity against L 1210 lymphoid leukemia whereas N,N bis(2 chloroethyl) 4 (ethoxycarbonyl)tetrahydro 2H 1,3,2 oxazaphosphorin 2 amine 2 oxide did not. The oxazaphosphorin 2 amine was evaluated against human epidermoid carcinoma of the nasopharynx (cell culture). The results again were negative: ED50=2.8x10.