673487-28-0Relevant academic research and scientific papers
Synthesis of novel histamine H4 receptor antagonists
Lane, Charlotte A.L.,Hay, Duncan,Mowbray, Charles E.,Paradowski, Michael,Selby, Matthew D.,Swain, Nigel A.,Williams, David H.
scheme or table, p. 1156 - 1159 (2012/03/11)
This letter describes the discovery and synthesis of a series of octahydropyrrolo[3,4-c]pyrrole based selective histamine hH4 receptor antagonists. The amidine compound 20 was found to be a potent and selective histamine H4 receptor antagonist with moderate clearance and a high volume of distribution.
Octahydropyrrolo[3,4-C]pyrrole derivatives
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Page/Page column 13, (2010/11/08)
The present invention relates to octahydropyrrolo[3,4-c]pyrrole derivatives of formula (I): and to processes for the preparation thereof, compositions containing the same and the uses thereof.
