6737-16-2Relevant academic research and scientific papers
Low pressure carbonylation of heterocycles
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Page/Page column 4, (2008/06/13)
Heterocycles, e.g., epoxides, are carbonylated at low pressure with high percentage conversion to cyclic, ring expanded products using the catalyst where L is tetrahydrofuran (THF).
Practical β-lactone synthesis: Epoxide carbonylation at 1 atm
Kramer, John W.,Lobkovsky, Emil B.,Coates, Geoffrey W.
, p. 3709 - 3712 (2007/10/03)
A readily prepared bimetallic catalyst is capable of effecting epoxide carbonylation to produce β-lactones at substantially lower CO pressures than previously reported catalyst systems. A functionally diverse array of β-lactones is produced in excellent yields at CO pressures as low as 1 atm. This procedure allows for epoxide carbonylation on a multigram scale without the requirement of specialized, high-pressure equipment.
