67372-68-3

Basic information

• Product Name: 6,7-DeMethylene Drospirenone
• Synonyms: 6,7-DeMethylene Drospirenone;(15α,16α,17α)-15,16-Dihydro-17-hydroxy-3-oxo-3'H-cyclopropa[15,16]pregna-4,15-diene-21-carboxylic Acid γ-Lactone;15β,16β-Methylene-3-oxo-17α-pregn-4-ene- 21,17-carbolactone;17β-Hydroxy-15β,16β-Methylene-3-oxo-17α-pregn-4-en;Drospirenone Related Impurity 1
• CAS NO: 67372-68-3
• Molecular Formula: C23H30O3
• Molecular Weight: 354.4825
• Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Steroids
• Mol File: 67372-68-3.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Storage Temp.: Hygroscopic, Refrigerator, Under Inert Atmosphere
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 6,7-DeMethylene Drospirenone(CAS DataBase Reference)
• NIST Chemistry Reference: 6,7-DeMethylene Drospirenone(67372-68-3)
• EPA Substance Registry System: 6,7-DeMethylene Drospirenone(67372-68-3)

Safety Data

• Hazardous Substances Data: 67372-68-3(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

Different sources of media describe the Uses of 67372-68-3 differently. You can refer to the following data:
1. 6,7-Demethylene Drospirenone (Drospirenone EP Impurity A) is an intermediate in the synthesis of Drospirenone (D689500). Drospirenone impurity.
2. An intermediate in the synthesis of Drospirenon

Upstream product

• 81721-30-4 3β-hydroxy-15β,16β-methylene-17α-pregn-5-ene-21,17-carbolactone 

Downstream Products

• 101765-35-9 6,6-ethylene-15β,16β-methylene-3-oxo-17α-pregn-4-ene-21,17-carbolactone 

Relevant articles and documents

Epoxidation of 17-oxo-15,16-methylene steroids with sulfoxonium ylides

A process for the epoxidation of 17-oxo-15,16-methylene steroids, in particular of drospirenone precursors, comprising the use of sulfoxonium ylides, in particular of dimethylsulfoxonium methyl ylide. The process allows to prepare in good yields 17-spiro epoxides, which can be easily transformed into 17-spironolacto-steroids.