67382-37-0Relevant academic research and scientific papers
Synthesis of a new series of pyrazolo[1,5-a]pyrimidines structurally related to zaleplon
Baraldi, Pier Giovanni,Fruttarolo, Francesca,Tabrizi, Mojgan Aghazadeh,Romagnoli, Romeo,Preti, Delia,Ongini, Ennio,El-Kashef, Hussein,Carrion, Maria Dora,Borea, Pier Andrea
, p. 355 - 361 (2008/04/12)
(Chemical Equation Presented) The reaction between 3-(dimethylamino)/3,3- bis(methylthio)-1-(substituted)prop-2-en-1-ones and 4-substituted-5-amino-1H- pyrazoles afforded new pyrazole[1,5-a]pyrimidines structurally related to Zaleplon. The chemical modifications introduced at the 3-, 5-, and 7-positions of the bicyclic structure revealed new promising candidates for the treatment of sleep disorders.
Anti-cancer compounds
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, (2008/06/13)
The present invention relates to 2-substituted 4-heteroaryl-pyrimidines, their preparation, pharmaceutical compositions containing them and their use as inhibitors of cyclin-dependent kinases (CDKs) and hence their use in the treatment of proliferative disorders such as cancer, leukaemia, psoriasis and the like.
