67382-40-5

Upstream product

• 110-62-3 pentanal 
• 108-94-1 cyclohexanone 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 71-43-2 benzene 
• 120-92-3 cyclopentanone 
• 28467-36-9 2-(dimethylaminomethylene)cyclohexane-1-one 
• 693-04-9 butyl magnesium bromide 

Downstream Products

• 6626-32-0 2,6-di-n-propylphenol 
• 116374-97-1 2,6-dipentylphenol 
• 116375-05-4 2-heptyl-6-pentylphenol 
• 116375-03-2 2-pentyl-6-propylphenol 
• 116375-04-3 2-butyl-6-pentylphenol 

Relevant academic research and scientific papers

A new lewis acid system palladium/TMSCl for Catalytic aldol condensation of aldehydes with ketones

Palladium on charcoal effectively catalyzed the aldol condensation reactions of different ketones with aldehydes in the presence of trimethylsilyl chloride (TMSCl). The following reactions were investigated: (1) aromatic aldehydes with cycloalkanones, (2) aromatic aldehydes with aromatic ketones, (3) cycloalkanones with aliphatic aldehydes, and (4) the self-condensation reactions of aliphatic aldehydes and cycloalkanones.

The reaction of enaminones with grignard reagents: Synthesis of α,β- unsaturated ketones

Enaminones in toluene react with Grignard reagents in tetrahydrofuran at 0-25 °C, to give selectively and with high yields the corresponding α,β- unsaturated ketones.

Cross-Condensation Reactions of Cycloalkanones with Aldehydes and Primary Alcohols under the Influence of Zirconocene Complexes.

Under the influence of zirconocene complex,Cp2ZrH2 (1) or Cp2Zr(O-i-Pr)2 (9),cycloalkanones 2 condensed directly with aliphatic aldehydes 3 or primary alcohols 7 to form 2-alkylidenecycloalkanones 4 or 2-alkyl-2-cycloalken-1-ones 8,respectively,in fair to substantial yields.The selectivity of the cross-condensations was slighty improved by using 1 in combination with a metal salt such as NiCl2.Dihydrojasmone (13) was synthesized in 35percent yield by one-step reaction from the commercially available 3-methylpentanone (2e) with pentanol (7b) in the presence of 1 and NiCl2.

α,β-Unsaturated ketones and aldehydes and method of preparation

α,β-Unsaturated ketones and aldehydes, together with a method of preparation thereof which comprises reacting aldehydes and cyclic and acyclic ketones possessing a methyl or methylene group α- to the carbonyl function with N,N-dialkylformamide dialkyl acetal to yield the corresponding enaminoketones and enaminoaldehydes, which enaminoketones and enaminoaldehydes are allowed to react with alkyllithium reagents to yield the corresponding nitrogen-free 2-alkylidene ketones and 2-alkylidene aldehydes.